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|1. (WO2018137294) TRANSGENIC LYMPHOCYTE CO-EXPRESSING ANTI-MSLN CHIMERIC ANTIGEN RECEPTOR AND NON-FUNCTIONAL EGFR AND USE THEREOF|
|Applicants:||BEIJING MARINO BIOTECHNOLOGY PTY LTD.
|Title:||TRANSGENIC LYMPHOCYTE CO-EXPRESSING ANTI-MSLN CHIMERIC ANTIGEN RECEPTOR AND NON-FUNCTIONAL EGFR AND USE THEREOF|
Provided are a transgenic lymphocyte, a construct, and a therapeutic composition for treating a cancer. The transgenic lymphocyte expresses a non-functional EGFR and a chimeric antigen receptor. The chimeric antigen receptor comprises an extracellular domain, and the extracellular domain comprises a heavy chain variable region and a light chain variable region of a single-chain antibody. The single-chain antibody specifically recognizes an antigen, MSLN. The chimeric antigen receptor further comprises a transmembrane domain. The transmembrane domain is connected with the extracellular domain and is embedded in the membrane of the lymphocyte. The chimeric antigen receptor further comprises an intracellular domain. The intracellular domain is connected with the transmembrane domain and comprises an intracellular segment of CD28 or 4-1BB and a CD3ζ chain.