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1. (WO2018137028) METHODS, COMPOSITIONS AND KITS FOR ASSESSING BRAIN INFLAMMATION IN DEPRESSION AND RELATED CONDITIONS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/137028 International Application No.: PCT/CA2018/050081
Publication Date: 02.08.2018 International Filing Date: 24.01.2018
IPC:
G01N 33/48 (2006.01) ,A61B 5/05 (2006.01) ,G01N 33/88 (2006.01)
Applicants: CENTRE FOR ADDICTION AND MENTAL HEALTH[CA/CA]; Bell Gateway Building, 6th Floor 100 Stokes Street Toronto, Ontario M6J 1H4, CA
Inventors: MEYER, Jeffrey H.; CA
SETIAWAN, Elaine; CA
Agent: SCHROEDER, Hans; CA
BAKER, James D.; CA
BOWN, Christopher D.; CA
CRICHTON, Michael; CA
LEDWELL, M. Kent; CA
NEWTON, Trevor; CA
ROY, Matthew; CA
SPRIGINGS, Mark; CA
WILKIE, Jennifer; CA
Priority Data:
62/449,83624.01.2017US
Title (EN) METHODS, COMPOSITIONS AND KITS FOR ASSESSING BRAIN INFLAMMATION IN DEPRESSION AND RELATED CONDITIONS
(FR) PROCÉDÉS, COMPOSITIONS ET KITS D'ÉVALUATION D'UNE INFLAMMATION CÉRÉBRALE DANS LA DÉPRESSION ET DE CONDITIONS ASSOCIÉES
Abstract:
(EN) Disclosed are methods, compositions and kits for assessing the level of brain inflammation in depressed subjects and assessing, preventing or inhibiting the chronological advancement of depression, including neuroprogression. The methods involve blood tests, comprising the quantification of blood prostaglandin E2 (PGE2), prostaglandin D2 (PGD2), or a combination thereof; or positron emission tomography (PET) scans, comprising measuring translocator protein (TSPO) binding.
(FR) L'invention concerne des procédés, des compositions et des kits permettant l'évaluation du niveau d'inflammation cérébrale chez des sujets déprimés et l'évaluation, la prévention ou l'inhibition de l'avancement chronologique de la dépression, y compris la neuroprogression. Les procédés impliquent des tests sanguins, comprenant la quantification de la prostaglandine sanguine E2 (PGE2), de la prostaglandine D2 (PGD2), ou d'une combinaison de ces dernières ; ou des balayages de tomographie par émission de positrons (TEP), comprenant la mesure de la liaison de la protéine translocatrice (TSPO).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)