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1. (WO2018136819) PORTABLE WIDE FIELD FLUORIMETER SYSTEMS

Pub. No.:    WO/2018/136819    International Application No.:    PCT/US2018/014563
Publication Date: Fri Jul 27 01:59:59 CEST 2018 International Filing Date: Sat Jan 20 00:59:59 CET 2018
IPC: C12Q 1/00
G01N 21/00
G01N 21/75
G01N 33/00
G01N 33/48
G01N 33/543
Applicants: THE GENERAL HOSPITAL CORPORATION
Inventors: PALANISAMI, Akilan
HASAN, Tayyaba
Title: PORTABLE WIDE FIELD FLUORIMETER SYSTEMS
Abstract:
The present disclosure features portable wide field fluorimeter systems, e.g., in the form of low-cost mobile platforms, and methods to perform fluorometric assays to detect a change in fluorescence intensity in liquid samples, e.g., caused by the presence of a target analyte, e.g., a protein, e.g., an enzyme (e.g., β-lactamase) expressed by a target pathogen in a liquid sample in a point-of-care setting. In some implementations, a portable system for detecting a change in fluorescence intensity in a liquid sample includes a microfluidic device, an optical assembly including an emission filter and one or more lenses, and an analyzer device that collects and processes a fluorescent signal for the detection of a target analyte produced by the target pathogen present in the liquid sample.