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1. WO2018136708 - COMPOSITIONS AND METHODS OF TREEATING AUTOIMMUNE DISEASE BY REDUCING ENTEROCOCCUS

Publication Number WO/2018/136708
Publication Date 26.07.2018
International Application No. PCT/US2018/014368
International Filing Date 19.01.2018
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
C07K 16/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12against material from bacteria
CPC
A61K 2039/521
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
52Bacterial cells; Fungal cells; Protozoal cells
521inactivated (killed)
A61K 31/7088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 38/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
14Peptides containing saccharide radicals; Derivatives thereof ; , e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
A61K 39/09
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus; , streptococcus
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
Applicants
  • YALE UNIVERSITY [US]/[US]
Inventors
  • KRIEGEL, Martin, A.
  • VIERIA, Silvio, Manfredo
Agents
  • SINGH, Pallab
  • FONVILLE, Natalie
  • ALLEN, Justin
  • CHEN, Ming
  • ARTIS, Ryan
Priority Data
62/448,11919.01.2017US
62/448,51020.01.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS OF TREEATING AUTOIMMUNE DISEASE BY REDUCING ENTEROCOCCUS
(FR) COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT D’UNE MALADIE AUTO-IMMUNE PAR RÉDUCTION D’ENTEROCOCCUS
Abstract
(EN)
The present invention relates to compositions and methods for treating or preventing an autoimmune disorder by reducing the amount or activity of Enterococcus sp. in a subject. In certain aspects, the present invention provides methods of diagnosing a subject as having an autoimmune disease or disorder by detecting an increased amount of Enterococcus sp. or anti -Enterococcus sp. antibodies in the subject.
(FR)
La présente invention concerne des compositions et des procédés de traitement ou de prévention d’un trouble auto-immun par réduction de la quantité ou de l’activité d’Enterococcus sp. chez un sujet. Dans certains aspects, la présente invention concerne des procédés de diagnostic d’un sujet comme étant atteint d’une maladie ou un trouble auto-immun par détection d’une quantité accrue d’Enterococcus sp. ou d’anticorps anti-Enterococcus sp. chez le sujet.
Also published as
Latest bibliographic data on file with the International Bureau