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1. (WO2018136455) ENDOLYSOSOMAL TARGETING CONJUGATES FOR IMPROVED DELIVERY OF CARGO MOLECULES TO THE ENDOLYSOSOMAL COMPARTMENT OF TARGET CELLS
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Pub. No.: WO/2018/136455 International Application No.: PCT/US2018/013952
Publication Date: 26.07.2018 International Filing Date: 17.01.2018
IPC:
A61K 47/66 (2017.01) ,A61K 47/68 (2017.01) ,A61K 39/44 (2006.01) ,A61K 38/38 (2006.01) ,A61K 49/00 (2006.01) ,A61K 49/16 (2006.01) ,A61K 51/08 (2006.01) ,A61K 51/10 (2006.01) ,C07K 16/46 (2006.01) ,A61P 35/00 (2006.01)
[IPC code unknown for A61K 47/66][IPC code unknown for A61K 47/68]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44
Antibodies bound to carriers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
38
Albumins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08
characterised by the carrier
10
Organic compounds
14
Peptides, e.g. proteins
16
Antibodies; Immunoglobulins; Fragments thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
08
Peptides, e.g. proteins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
08
Peptides, e.g. proteins
10
Antibodies or immunoglobulins; Fragments thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
THE TEXAS A&M UNIVERSITY SYSTEM [US/US]; 3369 TAMU College Station, TX 77843-3369, US
Inventors:
OBER, Elizabeth Sally Ward; US
OBER, Raimund Johannes; US
KANG, Jeffrey Che-Wei; US
SUN, Wei; US
Agent:
LECOINTE, Michelle; US
Priority Data:
62/447,26517.01.2017US
62/447,41117.01.2017US
Title (EN) ENDOLYSOSOMAL TARGETING CONJUGATES FOR IMPROVED DELIVERY OF CARGO MOLECULES TO THE ENDOLYSOSOMAL COMPARTMENT OF TARGET CELLS
(FR) CONJUGUÉS DE CIBLAGE ENDOLYSOSOMAL POUR UNE MEILLEURE DISTRIBUTION DE MOLÉCULES DE CHARGE AU COMPARTIMENT ENDOLYSOSOMAL DE CELLULES CIBLES
Abstract:
(EN) Endolysosomal targeting conjugates that are engineered to deliver cargo molecules such as cytotoxic drugs or imaging labels with improved efficiency to late endosomes and/or lysosomes in target cells such as tumor cells are described. The endolysosomal targeting conjugate includes a targeting component and a cargo component. The targeting component is configured to bind to a cell surface molecule of a target cell and the cargo component includes a cargo molecule. The targeting component and the cargo component may be fused by a covalent bond or associated by a non-covalent bond. The targeting component may bind to the cell surface molecule or the cargo component with higher affinity in the extracellular space than in an endolysosomal compartment of the target cell.
(FR) L'invention concerne des conjugués de ciblage endolysosomal qui sont modifiés pour distribuer avec une meilleure efficacité les molécules dont ils sont chargés, telles que des médicaments cytotoxiques ou des marqueurs d'imagerie, à des endosomes tardifs et/ou des lysosomes situés dans des cellules cibles telles que des cellules tumorales. Le conjugué de ciblage endolysosomal comprend un constituant à rôle de ciblage et un constituant de type charge. Le constituant à rôle de ciblage est configuré pour se lier à une molécule de la surface cellulaire de la cellule cible et le constituant de type charge comprend une molécule cargo. Le constituant à rôle ciblage et le constituant de type charge peuvent être fusionnés par une liaison covalente ou associés par une liaison non covalente. Le constituant à rôle de ciblage peut se lier à la molécule de la surface cellulaire ou au constituant de type charge avec une plus haute affinité dans l'espace extracellulaire que dans un compartiment endolysosomal de la cellule cible.
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African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)