Processing

Please wait...

Settings

Settings

Goto Application

1. WO2018135907 - SCHWANN CELL PRECURSOR AND METHOD FOR PREPARING SCHWANN CELL DIFFERENTIATED THEREFROM

Publication Number WO/2018/135907
Publication Date 26.07.2018
International Application No. PCT/KR2018/000910
International Filing Date 19.01.2018
IPC
C12N 5/079 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
079Neural cells
C12N 5/071 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
A61K 35/30 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
CPC
A61K 35/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants
  • 한국생명공학연구원 KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY [KR]/[KR]
Inventors
  • 조이숙 CHO, Yee Sook
  • 김한섭 KIM, Han-Seop
Agents
  • 손민 SON, Min
Priority Data
10-2017-000963720.01.2017KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) SCHWANN CELL PRECURSOR AND METHOD FOR PREPARING SCHWANN CELL DIFFERENTIATED THEREFROM
(FR) PRÉCURSEUR DE CELLULES DE SCHWANN ET PROCÉDÉ DE PRÉPARATION DE CELLULES DE SCHWANN DIFFÉRENCIÉES À PARTIR DUDIT PRÉCURSEUR
(KO) 슈반 세포 전구체 및 이로부터 분화된 슈반 세포의 제조 방법
Abstract
(EN)
The present invention provides a method for preparing a Schwann cell precursor from a pluripotent stem cell, a method for preparing a Schwann cell precursor from an adult cell, and a method for preparing a Schwann cell from the prepared Schwann cell precursor. Also, the present invention provides a pharmaceutical composition comprising the Schwann cell precursor and the Schwann cell for preventing or treating a nerve disease, a cell therapy product and a preparation method therefor, a composition for inducing direct differentiation from a pluripotent stem cell to a Schwann cell, and a composition for differentiation from a Schwann cell precursor to a Schwann cell. Provided also are a Schwann cell precursor or a Schwann cell prepared by the method, and a screening kit comprising the same. The method for preparing a Schwann cell precursor from a pluripotent stem cell or an adult cell according to the present invention can produce a Schwann cell precursor rapidly and effectively, and the Schwann cell prepared from a Schwann cell precursor has myelination potential and neurotrophic factor release activity, thus finding applications in the prevention or treatment of a nerve disease.
(FR)
La présente invention concerne un procédé de préparation d’un précurseur de cellules de Schwann à partir d’une cellule souche pluripotente, un procédé de préparation d’un précurseur de cellules de Schwann à partir d’une cellule adulte, et un procédé de préparation d’une cellule de Schwann à partir du précurseur de cellules de Schwann préparé. La présente invention concerne également une composition pharmaceutique comprenant le précurseur de cellules de Schwann et la cellule de Schwann destinée à prévenir ou traiter une maladie nerveuse, un produit de thérapie cellulaire et son procédé de préparation, une composition d’induction de différenciation directe d’une cellule souche pluripotente à une cellule de Schwann, et une composition de différenciation d’un précurseur de cellules de Schwann à une cellule de Schwann. La présente invention concerne également un précurseur de cellules de Schwann ou une cellule de Schwann préparés selon le procédé, et un kit de criblage les comprenant. Le procédé de préparation d’un précurseur de cellules de Schwann à partir d’une cellule souche pluripotente ou d’une cellule adulte selon la présente invention peut produire un précurseur de cellules de Schwann rapidement et efficacement, et la cellule de Schwann préparée à partir d’un précurseur de cellules de Schwann présente un potentiel de myélinisation et une activité de libération de facteur neurotrophique, trouvant ainsi des applications dans la prévention ou le traitement d’une maladie nerveuse.
(KO)
본 발명은 다능성 줄기 세포로부터 슈반 세포 전구체를 제조하는 방법, 성체 세포로부터 슈반 세포 전구체를 제조하는 방법 및 상기 제조된 슈반 세포 전구체로부터 슈반 세포를 제조하는 방법을 제공한다. 또한, 상기 슈반 세포 전구체 및 슈반 세포를 포함하는 신경 질환 예방 또는 치료용 약학적 조성물, 세포 치료제 및 이를 제조하는 방법, 다능성 줄기 세포로부터 슈반 세포로의 직접 분화 유도용 조성물, 슈반 세포 전구체로부터 슈반 세포로의 분화용 조성물을 제공한다. 또한, 상기 방법으로 제조된 슈반 세포 전구체 또는 슈반 세포, 및 이를 포함하는 스크리닝용 키트를 제공한다. 본 발명의 다능성 줄기 세포 또는 성체 세포로부터 슈반 세포 전구체를 제조하는 방법으로 신속하고 효율적인 슈반 세포 전구체를 생산할 수 있고, 또한, 상기 슈반 세포 전구체로부터 제조된 슈반 세포는 미엘린 형성능 및 신경 영양 인자 분비능을 가져, 신경 질환의 예방 또는 치료에 사용될 수 있다.
Also published as
Latest bibliographic data on file with the International Bureau