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1. (WO2018135561) METHOD FOR DETERMINING THERAPEUTIC EFFICACY OF ALLERGEN IMMUNOTHERAPY

Pub. No.:    WO/2018/135561    International Application No.:    PCT/JP2018/001327
Publication Date: Fri Jul 27 01:59:59 CEST 2018 International Filing Date: Fri Jan 19 00:59:59 CET 2018
IPC: G01N 33/53
C12N 5/078
C12Q 1/06
Applicants: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
国立大学法人千葉大学
Inventors: IHARA, Fumie
伊原 史英
OKAMOTO, Yoshitaka
岡本 美孝
NAKAYAMA, Toshinori
中山 俊憲
SAKURAI, Daiju
櫻井 大樹
Title: METHOD FOR DETERMINING THERAPEUTIC EFFICACY OF ALLERGEN IMMUNOTHERAPY
Abstract:
The present invention addresses the problem of providing: a method for determining the therapeutic efficacy of an allergen immunotherapy on allergic rhinitis with high accuracy; and others. The fluctuation in the number of ST2+ CD4+ T cells and the fluctuation in the number of at least one type of CD4+ T cells selected from the group consisting of CD27- CD4+ T cells, CD161+ CD4+ T cells, IL-5+ CD4+ T cells and IL-13+ CD4+ T cells before and after the start of an allergen immunotherapy on allergic rhinitis are analyzed, and it is determined that the immunotherapy using an allergen is effective for an allergic rhinitis patient when both of the cells decrease.