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1. WO2018134848 - DIETARY SUPPLEMENTS FOR INHIBITING PDE5 AND INCREASING CGMP LEVELS

Publication Number WO/2018/134848
Publication Date 26.07.2018
International Application No. PCT/IN2018/050028
International Filing Date 19.01.2018
IPC
A61K 35/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
02from inanimate materials
04Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
A61K 36/185 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
A61K 36/19 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
19Acanthaceae (Acanthus family)
A01N 65/00 2009.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
65Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
CPC
A23L 33/10
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
A23L 33/105
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
105Plant extracts, their artificial duplicates or their derivatives
A61K 2236/15
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
10Preparation or pretreatment of starting material
15involving mechanical treatment, e.g. chopping up, cutting or grinding
A61K 2236/333
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
30Extraction of the material
33involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
333using mixed solvents, e.g. 70% EtOH
A61K 2236/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
50Methods involving additional extraction steps
51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
A61K 2236/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
50Methods involving additional extraction steps
53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Applicants
  • LAILA NUTRACEUTICALS [IN]/[IN]
Inventors
  • GOKARAJU, Ganga Raju
  • GOKARAJU, Rama Raju
  • GOLAKOTI, Trimurtulu
  • BHUPATHIRAJU, Kiran
  • GOKARAJU, Venkata Kanaka Ranga Raju
  • SENGUPTHA, Krishanu
  • ALLURI, Venkata Krishna Raju
Agents
  • P., ARUNA SREE
Priority Data
20174100232920.01.2017IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DIETARY SUPPLEMENTS FOR INHIBITING PDE5 AND INCREASING CGMP LEVELS
(FR) COMPLÉMENTS ALIMENTAIRES PERMETTANT D'INHIBER UNE ENZYME PDE5 ET D'AUGMENTER LES TAUX DE CGMP
Abstract
(EN) The invention discloses synergistic compositions comprising extracts, fractions or pure compounds derived from at least two herbs selected from Punica granatum, Mangifera indica and Garcinia mangostana for inhibiting the expression/production/activity of Phosphodiesterase 5 (PDE5) enzyme or for increasing cGMP levels in a male subject. The invention further discloses a method of inhibiting the expression/production/activity of Phosphodiesterase 5 (PDE5) enzyme, increasing cGMP levels and sexual arousal, treating/ alleviating various aspects of male sexual dysfunction or impotence such as erectile dysfunction, loss of libido, or orgasm/ejaculation disorders in a male subject by using a suitable dose of synergistic composition comprising extracts, fractions or pure compounds derived from at least two herbs selected from Punica granatum, Mangifera indica and Garcinia mangostana.
(FR) L'invention concerne des compositions synergiques comprenant des extraits, des fractions ou des composés purs dérivés d'au moins deux herbes choisies parmi Punica granatum, Mangifera indica et Garcinia mangostana permettant d'inhiber l'expression/la production/l'activité de l'enzyme phosphodiestérase 5 (PDE5) ou d'augmenter les taux de cGMP chez un sujet masculin. L'invention concerne en outre une méthode d'inhibition de l'expression/la production/l'activité de l'enzyme phosphodiestérase 5 (PDE5), d'augmentation des taux de cGMP et de l'excitation sexuelle, de traitement/de soulagement de divers aspects de dysfonctionnement sexuel masculin ou d'impuissance, tels qu'une dysérection, une perte de libido, ou des troubles d'orgasme/d'éjaculation chez un sujet masculin à l'aide d'une dose appropriée de composition synergique comprenant des extraits, des fractions ou des composés purs dérivés d'au moins deux herbes choisies parmi Punica granatum, Mangifera indica et Garcinia mangostana.
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