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1. (WO2018134335) SUBSTITUTED IMIDAZOPYRIDINPYRIMIDINES

Pub. No.:    WO/2018/134335    International Application No.:    PCT/EP2018/051266
Publication Date: Fri Jul 27 01:59:59 CEST 2018 International Filing Date: Sat Jan 20 00:59:59 CET 2018
IPC: C07D 519/00
A61K 31/519
A61P 35/00
Applicants: BAYER PHARMA AKTIENGESELLSCHAFT
BAYER AKTIENGESELLSCHAFT
Inventors: KLAR, Ulrich
SCHÄCKE, Heike
SÜLZLE, Detlev
MENZ, Stephan
Title: SUBSTITUTED IMIDAZOPYRIDINPYRIMIDINES
Abstract:
The present invention relates to substituted imidazopyridinpyrimidine compounds of general formula (I) which inhibit MKNK1 and MKNK2 kinase (also known as MAP Kinase interacting Kinase, Mnkl and Mnk2), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative, angiogenesis disorders, inflammatory diseases or diseases associated with inflammatory pain, as a sole agent or in combination with other active ingredients.