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1. (WO2018134305) HYBRID NUCLEIC ACID MOLECULES AND THEIR USE

Pub. No.:    WO/2018/134305    International Application No.:    PCT/EP2018/051214
Publication Date: Fri Jul 27 01:59:59 CEST 2018 International Filing Date: Fri Jan 19 00:59:59 CET 2018
IPC: C12N 15/62
C12Q 1/68
C12N 15/113
C12N 15/115
C12N 15/63
Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
UNIVERSITE DE MONTPELLIER
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Inventors: BIENVENU, Frédéric
Title: HYBRID NUCLEIC ACID MOLECULES AND THEIR USE
Abstract:
The invention relates to a nucleic acid molecule comprising : a. a first region comprising a nucleic acid sequence coding for the protein Cyclin D1, also called CCND1, said first region being controlled by means allowing the expression of said protein, and b. at least one second region, said second region comprising essentially a sequence from 14 to 59 nucleic acids, said second region corresponding to a transcribed region of a gene, said second region containing at least a genetic modification compared to the same region of the corresponding wild-type version of said gene, said second region being genetically isolated from the means allowing the expression of said protein such that said second region is not translated into a peptide.