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1. (WO2018134232) MALDI DEVICE AND METHODS OF PREPARATION AND USE THEREOF

Pub. No.:    WO/2018/134232    International Application No.:    PCT/EP2018/051080
Publication Date: Fri Jul 27 01:59:59 CEST 2018 International Filing Date: Thu Jan 18 00:59:59 CET 2018
IPC: H01J 49/04
Applicants: ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE
Inventors: LIU, Baohong
LIANG, Qiao
JOVIC, Milica
ZHU, Yingdi
PICK, Horst
GIRAULT, Hubert
Title: MALDI DEVICE AND METHODS OF PREPARATION AND USE THEREOF
Abstract:
A target plate for enhanced matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) analysis of intact biological entities. The target plate comprises an electrically conductive substrate (1) covered at least partially with immobilised photo-reactive nanoparticles (2), acting as a photosensitizer and an ionization device, which drives efficient electron-transfer and radical reactions causing in-source disruption of the envelope structure of intact biological entities (3) and helps in desorption/ionization of components such as lipids, peptides and proteins from the intact biological entities to the MS analyser.