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1. (WO2018133921) ORGAN PRESERVATION AND/OR PERFUSION SOLUTIONS

Pub. No.:    WO/2018/133921    International Application No.:    PCT/EP2017/050881
Publication Date: Fri Jul 27 01:59:59 CEST 2018 International Filing Date: Wed Jan 18 00:59:59 CET 2017
IPC: A01N 1/02
Applicants: XVIVO PERFUSION AB
Inventors: SJÖQVIST, Elin
SIGVARDSSON, Anne-Li
Title: ORGAN PRESERVATION AND/OR PERFUSION SOLUTIONS
Abstract:
An organ preservation and/or perfusion solution for an isolated tissue or organ is provided. The solution comprises dextran, glucose, calcium ions, a buffer, and water, has a pH of 6,6 to 7,8, and is sterile based on having been subjected to heat sterilization. A method of preparing the solution also is provided. The method comprises combining dextran, glucose, calcium ions, buffer, and water to obtain an initial solution, adjusting the pH of the initial solution to 7,0 to 7,8 if needed, and subjecting the initial solution to heat sterilization, thereby obtaining the organ preservation and/or perfusion solution. A method of preserving and/or perfusing an isolated tissue or organ also is provided. A method for flushing, storage, and/or transportation of an isolated lung after removal from a donor in preparation for eventual transplantation into a recipient also is provided.