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1. (WO2018133910) METHOD FOR PREPARING ELECTROSPUN FIBERS WITH A HIGH CONTENT OF A BIOADHESIVE SUBSTANCE

Pub. No.:    WO/2018/133910    International Application No.:    PCT/DK2018/050010
Publication Date: Fri Jul 27 01:59:59 CEST 2018 International Filing Date: Tue Jan 23 00:59:59 CET 2018
IPC: A61K 9/70
A61K 31/573
Applicants: DERMTREAT APS
Inventors: HANSEN, Jens
Title: METHOD FOR PREPARING ELECTROSPUN FIBERS WITH A HIGH CONTENT OF A BIOADHESIVE SUBSTANCE
Abstract:
The present invention relates to a method for preparing electrospun fibers, the method comprising v) dissolving a fiber-forming hydrophilic polymer in an alcohol selected from C1-C3 alcohols, vi) dissolving a bioadhesive substance in water, wherein the bioadhesive substance has a solubility in water of 3 g/100 ml or more at 25 °C or g/100 ml or more at 25 °C, and wherein the bioadhesive substance has a solubility in an alcohol selected from C1-C3 alcohols of 0.5 g/100 ml 10 or less at 25 °C or 0.1g/100 ml or less at 25 °C, vii) adding under stirring the resulting solution from ii) to the resulting solu- tion from i), whereby the bioadhesive substance precipitates and a ho- mogeneous suspension is formed, wherein the bioadhesive substance is suspended as particles, and viii) electrospinning the homogeneous suspension to obtain hydrophilic fi- bers.