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1. (WO2018132920) PEPTIDE INHIBITOR OF TRANSMEMBRANE PORE FORMATION AND EFFLUXPUMP FUNCTION IN A SMALL MULTIDRUG RESISTANCE PROTEIN FROM PSEUDOMONAS AERUGINOSA

Pub. No.:    WO/2018/132920    International Application No.:    PCT/CA2018/050064
Publication Date: Fri Jul 27 01:59:59 CEST 2018 International Filing Date: Sat Jan 20 00:59:59 CET 2018
IPC: C07K 14/195
A61K 38/10
A61K 38/16
A61K 47/51
A61K 47/66
A61P 31/04
C07K 1/107
C07K 14/00
C07K 7/08
Applicants: THE HOSPITAL FOR SICK CHILDREN
Inventors: DEBER, Charles M.
Title: PEPTIDE INHIBITOR OF TRANSMEMBRANE PORE FORMATION AND EFFLUXPUMP FUNCTION IN A SMALL MULTIDRUG RESISTANCE PROTEIN FROM PSEUDOMONAS AERUGINOSA
Abstract:
A peptide comprises the sequence: X1-X2-(G or S)-X3-X4-L-(I or M)-X5-X6-G-(V or I)-X7X8 wherein each of X1-X8 is independently any amino acid and is independently present or absent; wherein the peptide has fewer than 30 amino acid residues; and wherein the peptide binds to and inhibits an efflux pump, with the proviso that the peptide does not comprise VVGLALIVAGVVV or VVGLALINAGVVV