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1. (WO2018132920) PEPTIDE INHIBITOR OF TRANSMEMBRANE PORE FORMATION AND EFFLUXPUMP FUNCTION IN A SMALL MULTIDRUG RESISTANCE PROTEIN FROM PSEUDOMONAS AERUGINOSA
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/132920 International Application No.: PCT/CA2018/050064
Publication Date: 26.07.2018 International Filing Date: 19.01.2018
IPC:
C07K 14/195 (2006.01) ,A61K 38/10 (2006.01) ,A61K 38/16 (2006.01) ,A61K 47/51 (2017.01) ,A61K 47/66 (2017.01) ,A61P 31/04 (2006.01) ,C07K 1/107 (2006.01) ,C07K 14/00 (2006.01) ,C07K 7/08 (2006.01)
Applicants: THE HOSPITAL FOR SICK CHILDREN[CA/CA]; 686 Bay Street 3rd Floor Toronto, Ontario M5G 0A4, CA
Inventors: DEBER, Charles M.; CA
Agent: LOWTHERS, Erica L.; CA
BARTOSZEWICZ, Lola A.; CA
CHEUNG, Sumei; CA
MCMANUS, Kimberly A.; CA
SABETA, Tony; CA
SINDEN, Kitt; CA
Priority Data:
62/449,06622.01.2017US
Title (EN) PEPTIDE INHIBITOR OF TRANSMEMBRANE PORE FORMATION AND EFFLUXPUMP FUNCTION IN A SMALL MULTIDRUG RESISTANCE PROTEIN FROM PSEUDOMONAS AERUGINOSA
(FR) INHIBITEUR PEPTIDIQUE DE LA FORMATION DE PORES TRANSMEMBRANAIRES ET DE LA FONCTION DE POMPE D'EFFLUX DANS UNE PETITE PROTÉINE DE MULTIRÉSISTANCE AUX MÉDICAMENTS ISSUE DE PSEUDOMONAS AERUGINOSA
Abstract: front page image
(EN) A peptide comprises the sequence: X1-X2-(G or S)-X3-X4-L-(I or M)-X5-X6-G-(V or I)-X7X8 wherein each of X1-X8 is independently any amino acid and is independently present or absent; wherein the peptide has fewer than 30 amino acid residues; and wherein the peptide binds to and inhibits an efflux pump, with the proviso that the peptide does not comprise VVGLALIVAGVVV or VVGLALINAGVVV
(FR) Selon l'invention, un peptide comprend la séquence : X1-X2-(G ou S)-X3-X4-L-(I or M)-X5-X6-G-(V ou I)-X7X8, chaque X1-X8 étant indépendamment n'importe quel acide aminé et étant indépendamment présent ou absent; le peptide ayant moins de 30 résidus d'acides aminés; et le peptide se liant à et inhibant une pompe d'efflux, à condition que le peptide ne comprenne pas VVGLALIVAGVVV ou VVGLALINAGVVV.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)