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1. WO2018132874 - METHOD OF PREVENTING AN IMMUNE RESPONSE WITH ALPHA- 1 ANTI-TRYPSIN

Publication Number WO/2018/132874
Publication Date 26.07.2018
International Application No. PCT/AU2018/050033
International Filing Date 18.01.2018
IPC
A61K 38/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
A61K 38/37 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
36Blood coagulation or fibrinolysis factors
37Factors VIII
A61P 7/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
04Antihaemorrhagics; Procoagulants; Haemostatatic agents; Antifibrinolytic agents
A61P 37/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
CPC
A61K 38/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
57from animals; from humans
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
A61P 7/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
04Antihaemorrhagics; Procoagulants; Haemostatatic agents; Antifibrinolytic agents
Applicants
  • CSL LIMITED [AU]/[AU]
Inventors
  • BAZ MORELLI, Adriana
  • BARR, Adele
Agents
  • FB RICE PTY LTD
Priority Data
201790015419.01.2017AU (Priority Withdrawn 15.07.2019)
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF PREVENTING AN IMMUNE RESPONSE WITH ALPHA- 1 ANTI-TRYPSIN
(FR) MÉTHODE PERMETTANT DE PRÉVENIR UNE RÉPONSE IMMUNITAIRE À L'AIDE D'ALPHA-1 ANTI-TRYPSINE
Abstract
(EN)
The present disclosure provides a method of preventing an immune response against a therapeutic protein in a subject, the method comprising administering a serine protease inhibitor, such as alpha-1 anti-trypsin or functional variant thereof, and a therapeutic protein to the subject. The present disclosure also provides compositions and/or kits comprising a serine protease inhibitor, such as alpha-1 anti-trypsin or functional variant thereof, and a therapeutic protein for use in preventing an immune response against a therapeutic protein in a subject.
(FR)
La présente invention concerne une méthode permettant de prévenir une réponse immunitaire contre une protéine thérapeutique chez un patient, la méthode comprenant l'administration au patient d'un inhibiteur de sérine protéase, tel que l'alpha-1 anti-trypsine ou un variant fonctionnel correspondant, et d'une protéine thérapeutique. La présente invention concerne également des compositions et/ou des kits comprenant un inhibiteur de sérine protéase, tel que l'alpha-1 anti-trypsine ou un variant fonctionnel correspondant, ainsi qu'une protéine thérapeutique, destinés à être utilisés pour prévenir une réponse immunitaire contre une protéine thérapeutique chez un patient.
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