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1. (WO2018132783) IMMUNOENGINEERED PLURIPOTENT CELLS

Pub. No.:    WO/2018/132783    International Application No.:    PCT/US2018/013688
Publication Date: Fri Jul 20 01:59:59 CEST 2018 International Filing Date: Mon Jan 15 00:59:59 CET 2018
IPC: C12N 5/074
A61K 35/545
C12N 15/113
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: SCHREPFER, Sonja
DEUSE, Tobias
Title: IMMUNOENGINEERED PLURIPOTENT CELLS
Abstract:
The invention provides pluripotent cells that are used therapeutically for regenerating tissues but avoid rejection by subjects that receive them. In particular, the invention provides hypo-immunogenic pluripotent cells that avoid host immune rejection. The cells lack major immune antigens that trigger immune responses and are engineered to avoid phagocytic endocytosis. The invention further provides universally acceptable "off-the-shelf" pluripotent cells and derivatives thereof for generating or regenerating specific tissues and organs.