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1. (WO2018132732) GENETICALLY ENCODED LIPID-POLYPEPTIDE HYBRID BIOMATERIALS THAT EXHIBIT TEMPERATURE TRIGGERED HIERARCHICAL SELF-ASSEMBLY

Pub. No.:    WO/2018/132732    International Application No.:    PCT/US2018/013611
Publication Date: Fri Jul 20 01:59:59 CEST 2018 International Filing Date: Sat Jan 13 00:59:59 CET 2018
IPC: A61K 31/185
A61K 31/19
A61K 31/20
A61K 38/08
C07K 4/00
C07K 4/12
C12N 9/10
Applicants: DUKE UNIVERSITY
Inventors: CHILKOTI, Ashutosh
MOZHDEHI, Davoud
LUGINBUHL, Kelli, M.
Title: GENETICALLY ENCODED LIPID-POLYPEPTIDE HYBRID BIOMATERIALS THAT EXHIBIT TEMPERATURE TRIGGERED HIERARCHICAL SELF-ASSEMBLY
Abstract:
Disclosed herein are conjugates including a fatty acid, a self-assembly domain, and a polypeptide, where the conjugates have phase transition behavior. Further disclosed are methods of using the conjugates to treat disease, methods of delivering an agent, and methods of preparing the conjugates.