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1. WO2018130542 - LANTHANIDE COMPLEXES COMPRISING DENDRIMERS

Publication Number WO/2018/130542
Publication Date 19.07.2018
International Application No. PCT/EP2018/050510
International Filing Date 10.01.2018
IPC
C07F 5/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
5Compounds containing elements of Groups 3 or 13 of the Periodic System
A61K 49/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08characterised by the carrier
A61K 49/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08characterised by the carrier
10Organic compounds
CPC
A61K 41/0071
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
0071PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
A61K 47/595
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
595Polyamides, e.g. nylon
A61K 49/0021
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
A61K 49/0028
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
0028Oxazine dyes
A61K 49/0032
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
0032Methine dyes, e.g. cyanine dyes
A61K 49/0054
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
005characterised by the carrier molecule carrying the fluorescent agent
0054Macromolecular compounds, i.e. oligomers, polymers, dendrimers
Applicants
  • UNIVERSITE D'ORLEANS [FR]/[FR]
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR]/[FR]
Inventors
  • PETOUD, Stéphane
  • ELISEEVA, Svetlana
  • MARTINIC, Ivana
  • PLACIDE, Virginie
  • SUZENET, Franck
  • DELATOUCHE, Régis
  • LECLERC, Joan
  • FOUCAULT-COLLET, Alexandra
  • COLLET, Guillaume
Agents
  • BLOT, Philippe
  • COLOMBIE, Damien
  • DOMENEGO, Bertrand
  • HABASQUE, Etienne
  • HOLTZ, Béatrice
  • NEYRET, Daniel
Priority Data
17 5024511.01.2017FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) LANTHANIDE COMPLEXES COMPRISING DENDRIMERS
(FR) COMPLEXES DE LANTHANIDES À BASE DE DENDRIMÈRES
Abstract
(EN)
The present invention relates to a complex comprising at least one dendrimer and at least one lanthanide, in which the dendrimer comprises a unit of formula (I), wherein: C1 is a group with a valency of 4 of formula >N-CH2-CH2-N<; and - A1, A2 and A3 are groups of formula -(CH2)2-C(O)-NH-(CH2)2-; said unit of formula (I) being covalently bound to at least one antenna that absorbs at a wavelength of between 500 nm and 900 nm.
(FR)
La présente invention concerne un complexe comprenant au moins un dendrimère et au moins un lanthanide, dans lequel le dendrimère comprend un motif de formule (I) suivante : dans laquelle : - C1 est un groupe de valence 4 de formule >N-CH2-CH2-N<; - A1, A2 et A3 sont des groupes de formule -(CH2)2-C(O)-NH-(CH2)2-; ledit motif de formule (I) étant relié de façon covalente à au moins une antenne qui absorbe à une longueur d'onde allant de 500 nm à 900 nm.
Also published as
Latest bibliographic data on file with the International Bureau