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1. WO2018130390 - INTRODUCTION OF ACTIVE SUBSTANCES THAT ARE HARDLY WATER-SOLUBLE OR WATER-INSOLUBLE INTO A HYDROPHILIC THREE-DIMENSIONAL NETWORK MADE OF CELLULOSE USING LIPID-BASED NANOPARTICLES/VESICLES

Publication Number WO/2018/130390
Publication Date 19.07.2018
International Application No. PCT/EP2017/083778
International Filing Date 20.12.2017
IPC
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor
A61K 9/51 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
A61K 31/122 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
122having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
CPC
A61K 31/7036
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034attached to a carbocyclic compound, e.g. phloridzin
7036having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
A61K 8/027
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
0241Containing particulates characterized by their shape and/or structure
027Fibers; Fibrils
A61K 8/0291
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
0291Micelles
A61K 8/062
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
04Dispersions; Emulsions
06Emulsions
062Oil-in-water emulsions
A61K 8/066
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
04Dispersions; Emulsions
06Emulsions
066Multiple emulsions, e.g. water-in-oil-in-water
A61K 8/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
14Liposomes; Vesicles
Applicants
  • BLUME, Gabriele [DE]/[DE]
Inventors
  • BLUME, Gabriele
  • FISCHER, Dagmar
  • ALKHATIB, Yaser
Agents
  • ADVOTEC. PATENT- UND RECHTSANWÄLTE
Priority Data
10 2017 000 368.816.01.2017DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) EINBRINGEN VON SCHWER UND/ODER NICHT WASSERLÖSLICHEN WIRKSTOFFEN MITTELS AUF LIPIDEN BASIERENDEN NANOPARTIKELN/VESIKELN IN EIN HYDROPHILES AUS CELLULOSE BESTEHENDES DREIDIMENSIONALES NETZWERK
(EN) INTRODUCTION OF ACTIVE SUBSTANCES THAT ARE HARDLY WATER-SOLUBLE OR WATER-INSOLUBLE INTO A HYDROPHILIC THREE-DIMENSIONAL NETWORK MADE OF CELLULOSE USING LIPID-BASED NANOPARTICLES/VESICLES
(FR) INTRODUCTION DE SUBSTANCES ACTIVES FAIBLEMENT SOLUBLES ET/OU NON SOLUBLES DANS L’EAU AU MOYEN DE NANOPARTICULES/VÉSICULES À BASE DE LIPIDES DANS UN RESEAU TRIDIMENSIONNEL HYDROPHILE DE CELLULOSE
Abstract
(DE)
Die vorliegende Erfindung beruht auf der Beladung von einem hydrophilen natürlichen drei-dimensionalen Netzwerk bestehend aus Cellulose-Nanofasern mit auf Lipiden basierenden dermalen Trägersystemen. Lipophile oder schwer wasserlösliche Wirkstoffe sowohl für den kosmetischen als auch für den pharmakologischen / pharmazeutischen / medizinischen Einsatz werden in die im Nanometerbereich liegenden Lipidpartikel verkapselt. Diese Nanopartikel liegen in wässriger Dispersion oder Lösung vor, wodurch die Einarbeitung von lipophilen Wirkstoffen in das auf hohem Wassergehalt basierende Hydro-Gel (Wassergehalt bis 99.99%) ermöglicht wird. Solche wirkstoffbeladenen Cellulose-Vliese lassen sich hervorragend in der Kosmetik für eine Vielzahl von unterschiedlichen Anwendungen einsetzen (u.a. Anti-Falten, Hautfeuchtigkeit, Regenerierung der Haut usw.). Sie können aber auch im medizinischen Bereich (u.a. zur Wundbehandlung z.B. hervorgerufen durch unterschiedliche Einwirkungen wie chronische Wunden, Verbrennungen, diabetische Bein- und Fußgeschwüre) sowie als Implantate (z.B. Knochen, Knorpel und Hautersatz, aber auch im dentalen Bereich) verwendet werden.
(EN)
The present invention is based on the loading of a hydrophilic natural three-dimensional network made of cellulose nanofibers with lipid-based dermal carrier systems. Lipophilic or hardly water-soluble active substances both for cosmetic and pharmacological/pharmaceutical/medical use are encapsulated in the lipid particles which are in the nanometer range. These nanoparticles are present in aqueous dispersion or solution, thus allowing incorporation of lipophilic active substances into the hydrogel which is based on a high water content (water content up to 99.99%). Such active substance-laden cellulose nonwoven structures are extremely useful in the field of cosmetics for a multiplicity of different applications (inter alia anti-wrinkle, skin moisture, skin regeneration etc). However, they may also be used in the field of medicine (inter alia for wound treatment necessitated for example by various factors such as chronic wounds, burns, diabetic leg and foot ulcers) and also as implants (for example bone, cartilage and skin replacement but also in the field of dentistry).
(FR)
La présente invention concerne le chargement d’un réseau tridimensionnel naturel hydrophile constitué de nanofibres de cellulose avec des systèmes de support dermiques à base de lipides. Les substances actives lipophiles ou faiblement solubles dans l’eau destinées à une utilisation à la fois cosmétique et pharmacologique/pharmaceutique/médicale sont encapsulées dans des particules lipidiques de l’ordre du nanomètre. Ces nanoparticules sont en dispersion ou en solution aqueuse, ce qui permet l’incorporation de substances actives lipophiles dans l’hydrogel à haute teneur en eau (teneur en eau jusqu’à 99,99%). De tels non-tissés de cellulose chargés de substances actives peuvent être utilisés de manière remarquable dans les produits cosmétiques pour une variété d’applications différentes (y compris les antirides, l’hydratation de la peau, la régénération de la peau, etc.). Cependant, ils peuvent également être utilisés dans le domaine médical (par exemple pour le traitement de plaies, par exemple pour les plaies chroniques, les brûlures, les ulcères des jambes et des pieds diabétiques) et comme implants (par exemple os, cartilage et substitut de peau, mais aussi dans le domaine dentaire).
Also published as
Latest bibliographic data on file with the International Bureau