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1. WO2018130132 - NUCLEAR MAGNETIC RESONANCE MULTIDIMENSIONAL SPECTRUM METHOD FOR MEASURING HYDROGEN-HYDROGEN COUPLING CONSTANTS OF A PLURALITY OF COUPLING NETWORKS

Publication Number WO/2018/130132
Publication Date 19.07.2018
International Application No. PCT/CN2018/071808
International Filing Date 08.01.2018
IPC
G01N 24/08 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
24Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
08by using nuclear magnetic resonance
CPC
G01N 24/08
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
24Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
08by using nuclear magnetic resonance
G01R 33/4608
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
46NMR spectroscopy
4608RF excitation sequences for enhanced detection, e.g. NOE, polarisation transfer, selection of a coherence transfer pathway
G01R 33/4616
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
46NMR spectroscopy
4616using specific RF pulses or specific modulation schemes, e.g. stochastic excitation, adiabatic RF pulses, composite pulses, binomial pulses, Shinnar-le-Roux pulses, spectrally selective pulses not being used for spatial selection
G01R 33/4625
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
46NMR spectroscopy
4625Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
G01R 33/4633
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance [NMR]
46NMR spectroscopy
4633Sequences for multi-dimensional NMR
Applicants
  • 厦门大学 XIAMEN UNIVERSITY [CN]/[CN]
Inventors
  • 林雁勤 LIN, Yanqin
  • 曾庆 ZENG, Qing
  • 陈金永 CHEN, Jinyong
  • 陈忠 CHEN, Zhong
Agents
  • 厦门市首创君合专利事务所有限公司 SHOUCHUANG JUNHE PATENT AGENT CO., LTD. XIAMEN
Priority Data
201710025922.113.01.2017CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) NUCLEAR MAGNETIC RESONANCE MULTIDIMENSIONAL SPECTRUM METHOD FOR MEASURING HYDROGEN-HYDROGEN COUPLING CONSTANTS OF A PLURALITY OF COUPLING NETWORKS
(FR) PROCÉDÉ DE SPECTRE MULTIDIMENSIONNEL PAR RÉSONANCE MAGNÉTIQUE NUCLÉAIRE PERMETTANT LA MESURE DE CONSTANTES DE COUPLAGE HYDROGÈNE-HYDROGÈNE D'UNE PLURALITÉ DE RÉSEAUX DE COUPLAGE
(ZH) 测量多个耦合网络的氢-氢耦合常数的核磁共振多维谱方法
Abstract
(EN)
A nuclear magnetic resonance multidimensional spectrum method for simultaneously measuring hydrogen-hydrogen coupling constants of a plurality of coupling networks, the method comprising: firstly applying a 90-degree hard pulse to rotate a magnetization vector from the Z direction to the XY plane; after the time of t1/2, applying a selective 180-degree soft pulse, and simultaneously applying a Z-direction magnetic field gradient, so that the selective 180-degree soft pulse excites different nuclei in different spatial locations; then applying a psyche module, and applying two gradients having the same strength and the same direction to both sides of the psyche module to disperse the phase of an unwanted signal; and then after the time of t1/2, using an EPSI sampling module to simultaneously acquire chemical shift information and spatial location information. In this way, the couplings of other nuclei and the nuclei excited by the 180-degree soft pulse in the same layer can be obtained in different layers, and these couplings show the split peaks in indirect dimensions; and a corresponding J coupling constant can be measured from these split peaks.
(FR)
L'invention concerne un procédé de spectre multidimensionnel par résonance magnétique nucléaire permettant la mesure simultanée de constantes de couplage hydrogène-hydrogène d'une pluralité de réseaux de couplage, le procédé comprenant : premièrement l'application d'une impulsion dure de 90 degrés afin de faire tourner un vecteur de magnétisation depuis la direction Z vers le plan XY ; après un temps de t1/2, l'application d'une impulsion souple à 180 degrés sélective et l'application simultanée d'un gradient de champ magnétique de direction Z, de telle sorte que l'impulsion souple à 180 degrés sélective excite différents noyaux dans différents emplacements spatiaux ; puis l'application d'un module psychique et l'application de deux gradients présentant la même résistance et la même direction des deux côtés du module psychique afin de disperser la phase d'un signal indésirable ; puis après un temps de t1/2, l'utilisation d'un module d'échantillonnage EPSI afin d'acquérir simultanément des informations de décalage chimique et des informations d'emplacement spatial. De cette manière, les couplages d'autres noyaux et des noyaux excités par l'impulsion souple à 180 degrés dans la même couche peuvent être obtenus dans différentes couches et lesdits couplages montrent les pics divisés en dimensions indirectes ; et une constante de couplage J correspondante peut être mesurée à partir desdits pics divisés.
(ZH)
一种同时测量多个耦合网络的氢-氢耦合常数的核磁共振多维谱方法,首先施加一个90度硬脉冲将磁化矢量从Z方向旋转到XY平面;在经历t 1/2时间后,施加一个选择性180度软脉冲,同时施加一个Z方向的磁场梯度,这样该选择性180度软脉冲在不同的空间位置激发不同的核;然后施加PSYCHE模块,在PSYCHE模块两边施加强度相同、方向相同的梯度用于对不需要的信号进行散相;然后再经历t 1/2时间后,采用EPSI采样模块,同时获取化学位移信息和空间位置信息。这样在不同层可以得到其他核和在同一层180度软脉冲所激发到的核的耦合,这些耦合会在间接维表现出裂峰;对应的J耦合常数就可以从这些裂峰中进行测量。
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