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1. (WO2018129536) THERAPEUTIC AND IMMUNOMODULATORY BACTERIOPHAGE FORMULATIONS AND METHODS FOR MAKING AND USING THEM

Pub. No.:    WO/2018/129536    International Application No.:    PCT/US2018/012983
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Wed Jan 10 00:59:59 CET 2018
IPC: A61K 35/76
C07K 14/005
C12N 7/00
C12N 15/79
C12N 15/86
Applicants: SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION, DBA SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventors: ROHWER, Forest
BARR, Jeremy J.
BLUMBERG, Richard S.
BAKER, Kristi D.
Title: THERAPEUTIC AND IMMUNOMODULATORY BACTERIOPHAGE FORMULATIONS AND METHODS FOR MAKING AND USING THEM
Abstract:
In alternative embodiments, provided are compositions, products of manufacture and methods for treating, ameliorating and preventing infections, disorders and conditions in animals including: delivering a (i) bacteriophage (ii) prophage, the phagemid or phage-like particle, (iii) general transducing agent (GTA), or small, tailed bacteriophage-like particle, (iv) Metamorphosis Associated Contractile structure (MACs) or (v) phage-derived product into a tissue, or the blood stream or lymphatic system of the animal, e.g., the mammal; or delivering to a tissue or organ of the animal; or treating a bacterial or viral infection in the animal; generating an immune response in the animal; or treating a disease or condition in an individual in need thereof; or delivering a payload or a composition, e.g., in vivo, to the animal, or labelling, tagging or coating a cell in vivo in the animal.