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1. (WO2018129514) METHODS AND COMPOSITIONS FOR CANCER THERAPIES THAT INCLUDE DELIVERY OF HALOGENATED THYMIDINES AND THYMIDINE PHOSPHORYLASE INHIBITORS IN COMBINATION WITH RADIATION

Pub. No.:    WO/2018/129514    International Application No.:    PCT/US2018/012914
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Wed Jan 10 00:59:59 CET 2018
IPC: A61K 31/505
A61K 31/513
A61K 31/7072
Applicants: SHUTTLE PHARMACEUTICALS, LLC
Inventors: GRINDROD, Scott
TIMOFEEVA, Olga
BROWN, Milton
JUNG, Mira
DRITSCHILD, Anatoly
Title: METHODS AND COMPOSITIONS FOR CANCER THERAPIES THAT INCLUDE DELIVERY OF HALOGENATED THYMIDINES AND THYMIDINE PHOSPHORYLASE INHIBITORS IN COMBINATION WITH RADIATION
Abstract:
Methods and formulations are provided for treating cancer and neoplastic diseases in conjunction with radiation therapy where such methods and formulations include a combination of a radiosensitizing agent that is metabolized by thymidine phosphorylase and a thymidine phosphorylase inhibitor that increases the half-life of the radiosensitizing agent.