WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018129474) T-CELL MODULATORY MULTIMERIC POLYPEPTIDES AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/129474 International Application No.: PCT/US2018/012830
Publication Date: 12.07.2018 International Filing Date: 08.01.2018
IPC:
C07K 14/705 (2006.01) ,A61K 38/00 (2006.01)
Applicants: CUE BIOPHARMA, INC.[US/US]; 675 West Kendall Street Cambridge, MA 02142, US
Inventors: SEIDEL, III, Ronald, D.; US
CHAPARRO, Rodolfo; US
Agent: BORDEN, Paula, A.; US
Priority Data:
62/444,09509.01.2017US
Title (EN) T-CELL MODULATORY MULTIMERIC POLYPEPTIDES AND METHODS OF USE THEREOF
(FR) POLYPEPTIDES MULTIMÈRES MODULATEURS DE LYMPHOCYTES T ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.
(FR) La présente invention concerne des polypeptides immunomodulateurs variants et des polypeptides de fusion comprenant les peptides immunomodulateurs variants. La présente invention concerne des polypeptides multimères modulateurs de lymphocytes T et des compositions les comprenant, les polypeptides multimères modulateurs de lymphocytes T comprenant un polypeptide immunomodulateur variant de l'invention. La présente invention concerne des acides nucléiques comprenant des séquences nucléotidiques codant pour les polypeptides multimères modulateurs de lymphocytes T ; et des cellules hôtes comprenant les acides nucléiques. La présente invention concerne des procédés de modulation de l'activité d'un lymphocyte T ; lesquels procédés comprennent la mise en contact du lymphocyte T avec un polypeptide multimère modulateur de lymphocytes T de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)