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1. (WO2018129470) REVERSING DEFICIENT HEDGEHOG SIGNALING RESTORES DEFICIENT SKELETAL REGENERATION

Pub. No.:    WO/2018/129470    International Application No.:    PCT/US2018/012823
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Tue Jan 09 00:59:59 CET 2018
IPC: A61K 38/00
A61K 38/17
A61K 38/18
A61K 39/00
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors: LONGAKER, Michael T.
WEISSMAN, Irving L.
TEVLIN, Ruth
CHAN, Charles K.F.
Title: REVERSING DEFICIENT HEDGEHOG SIGNALING RESTORES DEFICIENT SKELETAL REGENERATION
Abstract:
Methods and compositions are provided for the therapeutic use of hedgehog agents, for enhancing bone growth and regeneration in diabetic or pre-diabetic patients, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection or implantation at the site of an injury.