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1. (WO2018129440) COMPLEXES FOR GENE DELETION AND EDITING

Pub. No.:    WO/2018/129440    International Application No.:    PCT/US2018/012764
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Tue Jan 09 00:59:59 CET 2018
IPC: A61K 47/64
C12N 9/22
C12N 9/96
C12N 15/113
C12N 15/90
Applicants: UNIVERSITY OF MASSACHUSETTS
Inventors: CZECH, Michael, P.
SHEN, Yuefei
Title: COMPLEXES FOR GENE DELETION AND EDITING
Abstract:
Complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide are provided. Compositions and methods for delivery of complexes comprising a nucleic acid-guided endonuclease, a sequence-specific targeting nucleic acid and an amphipathic helical peptide to mammals for both research and therapeutic use are provided. Methods of treating or reducing one or more symptoms of type 2 diabetes, prediabetes and/or gestational diabetes are provided.