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1. (WO2018129429) DEVICE AND METHOD FOR ISOLATING EXTRACELLULAR VESICLES FROM BIOFLUIDS

Pub. No.:    WO/2018/129429    International Application No.:    PCT/US2018/012735
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Tue Jan 09 00:59:59 CET 2018
IPC: G01N 30/00
Applicants: UNIVERSITY OF ROCHESTER
Inventors: MCGRATH, James Lionel
LUCAS, Kilean Scott
CHUNG, Henry, Hung Li
Title: DEVICE AND METHOD FOR ISOLATING EXTRACELLULAR VESICLES FROM BIOFLUIDS
Abstract:
A device and method for isolating extracellular vesicles from biofluids is disclosed, A nanoporous silicon nitride membrane is provided with a tangential flow of biofluid, A pressure gradient through the nanoporous silicon nitride membrane facilitates capture of extracellular vesicles from the tangential flow vector of biofluid. Reversal of the pressure gradient results in the release of the extracellular vesicles for subsequent collection.