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1. (WO2018129429) DEVICE AND METHOD FOR ISOLATING EXTRACELLULAR VESICLES FROM BIOFLUIDS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/129429 International Application No.: PCT/US2018/012735
Publication Date: 12.07.2018 International Filing Date: 08.01.2018
IPC:
G01N 30/00 (2006.01)
Applicants: UNIVERSITY OF ROCHESTER[US/US]; 601 Elmwood Avenue, Box URV Rochester, NY 14642, US
Inventors: MCGRATH, James Lionel; US
LUCAS, Kilean Scott; US
CHUNG, Henry, Hung Li; US
Agent: GUNDERMAN, Robert, D.; US
Priority Data:
62/443,74908.01.2017US
Title (EN) DEVICE AND METHOD FOR ISOLATING EXTRACELLULAR VESICLES FROM BIOFLUIDS
(FR) DISPOSITIF ET PROCÉDÉ POUR ISOLER DES VÉSICULES EXTRACELLULAIRES DE FLUIDES BIOLOGIQUES
Abstract: front page image
(EN) A device and method for isolating extracellular vesicles from biofluids is disclosed, A nanoporous silicon nitride membrane is provided with a tangential flow of biofluid, A pressure gradient through the nanoporous silicon nitride membrane facilitates capture of extracellular vesicles from the tangential flow vector of biofluid. Reversal of the pressure gradient results in the release of the extracellular vesicles for subsequent collection.
(FR) La présente invention concerne un dispositif et un procédé pour isoler des vésicules extracellulaires de fluides biologiques. Une membrane nanoporeuse en nitrure de silicium est pourvue d'un flux tangentiel de fluide biologique. Un gradient de pression à travers la membrane nanoporeuse en nitrure de silicium facilite la capture de vésicules extracellulaires à partir du vecteur de flux tangentiel de biofluide. L'inversion du gradient de pression conduit à la libération des vésicules extracellulaires pour une collecte ultérieure.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)