Search International and National Patent Collections

1. (WO2018129402) COMPOSITIONS AND METHODS USED IN DIAGNOSING AND TREATING COLORECTAL CANCER

Pub. No.:    WO/2018/129402    International Application No.:    PCT/US2018/012696
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Sat Jan 06 00:59:59 CET 2018
IPC: A61K 48/00
A61P 35/00
C12N 15/11
C12N 15/113
C12Q 1/68
Applicants: OREGON HEALTH & SCIENCE UNIVERSITY
Inventors: ANAND, Sudarshan
TSIKITIS, Liana
Title: COMPOSITIONS AND METHODS USED IN DIAGNOSING AND TREATING COLORECTAL CANCER
Abstract:
Disclosed are methods of treating colorectal cancer that involve administering a composition comprising an effective amount of miR-451a to cells in the colorectal cancer and further treating the colorectal cancer cells with ionizing radiation. Also disclosed are methods of predicting whether a colorectal cancer in a subject will respond to ionizing radiation. These methods involve measuring the RNA expression of miR-451a, miR-1322, miR-133-3p, miR-1, miR-205-5p, miR-4521, CAB39, EMSY, or MEX3C in the sample and measuring the RNA expression of the same marker in a control.