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1. (WO2018129399) DRUG COMBINATION TREATMENTS USING BONE-TARGETING THERAPEUTICS FOR BONE AND BONE-RELATED DISEASE
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Pub. No.: WO/2018/129399 International Application No.: PCT/US2018/012693
Publication Date: 12.07.2018 International Filing Date: 05.01.2018
IPC:
A61K 31/675 (2006.01) ,A61P 19/08 (2006.01) ,A61P 35/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
675
having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
Applicants:
MBC PHARMA, INC. [US/US]; 12635 E. Montview Boulevard, Suite 100 Aurora, Colorado 80045, US
Inventors:
ZINNEN, Shawn; US
KARPEISKY, Alexander; US
Agent:
CROWLEY-WEBER, Cara L.; US
PRENDERGAST, Paul J.; US
Priority Data:
62/442,80605.01.2017US
Title (EN) DRUG COMBINATION TREATMENTS USING BONE-TARGETING THERAPEUTICS FOR BONE AND BONE-RELATED DISEASE
(FR) TRAITEMENTS DE POLYTHÉRAPIE UTILISANT DES AGENTS THÉRAPEUTIQUES CIBLANT LES OS POUR DES MALADIES OSSEUSES ET LIÉES AUX OS
Abstract:
(EN) Provided herein is a novel method for creating fixed, non-antagonistic molar ratios of drugs in and around the bone environment for desired periods of time. This method enables treating bone and bone-related disease by administering a pharmaceutical composition comprising a bone-targeted therapeutic agent able to release a drug payload from the bone surface, in addition to a second therapeutic agent. Such methods are useful in the treatment of bone and bone-related diseases, such as cancer-induced bone disease, osteomyelitis and bone infection, bone pain and inflammatory bone disease, metabolic disease, as well as others.
(FR) La présente invention concerne un nouveau procédé pour créer des rapports molaires fixes non antagonistes de médicaments dans et autour de l’environnement osseux pendant des durées souhaitées. Ce procédé permet de traiter une maladie osseuse et liée aux os par administration d’une composition pharmaceutique comprenant un agent thérapeutique ciblant les os capable de libérer une charge utile de médicament depuis la surface osseuse, en plus d’un deuxième agent thérapeutique. De tels procédés sont utiles dans le traitement de maladies osseuses et liées aux os, telles qu’une maladie osseuse induite par le cancer, l’ostéomyélite et une infection osseuse, une douleur osseuse et une maladie osseuse inflammatoire, une maladie métabolique, et d’autres.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)