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1. (WO2018129390) MICROMOTORS AND NANOMOTORS FOR GASTROINTESTINAL DIAGNOSIS AND TREATMENT APPLICATIONS

Pub. No.:    WO/2018/129390    International Application No.:    PCT/US2018/012678
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Sat Jan 06 00:59:59 CET 2018
IPC: A61K 9/50
A61K 9/54
A61K 47/02
A61K 47/32
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: WANG, Joseph
ZHANG, Liangfang
Title: MICROMOTORS AND NANOMOTORS FOR GASTROINTESTINAL DIAGNOSIS AND TREATMENT APPLICATIONS
Abstract:
Disclosed are nano/micromotor devices, systems, and methods for providing payloads in the gastrointestinal system. In one aspect, a micromotor for a gastrointestinal tract includes a micromotor body including a one or more material layers to provide a structure that surrounds a hollow interior region and has an opening to an exterior of the micromotor body; one or more particles including a biocompatible metal element, the one or more particles contained in the interior region of the micromotor body; a coating coupled to the structure of the micromotor body; and a payload material, in which the micromotor is structured to move in a fluid of a gastrointestinal system based on a reaction between the one or more particles and a constituent or a condition of the fluid, such that the reaction generates bubbles that accelerate out of the opening of the micromotor body to propel the micromotor in the fluid.