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1. (WO2018129345) METHODS FOR DECREASING INJURIES ASSOCIATED WITH INTRAOPERATIVE HYPOTENSION
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Pub. No.: WO/2018/129345 International Application No.: PCT/US2018/012623
Publication Date: 12.07.2018 International Filing Date: 05.01.2018
IPC:
A61K 31/047 (2006.01) ,A61K 31/20 (2006.01) ,A61K 31/661 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
047
having two or more hydroxy groups, e.g. sorbitol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
20
having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
661
Phosphorus acids or esters thereof not having P-C bonds, e.g. fosfosal, dichlorvos, malathion
Applicants:
RESQ PHARMA, INC. [US/US]; 2442 W. Harrison Street Chicago, Illinois 60612, US
Inventors:
WEINBERG, Guy; US
Agent:
KIRLEY, J. Morgan; US
RILEY-VARGAS, Rebecca; US
DOTY, Kathryn; US
BISSEN, Shirley T.; US
KREPEL, Allison; US
JOHNSON, Charles A.; US
ROBERTS, Brett J.; US
NEALEY, Tara A.; US
DEAN, III, Elton F.; US
Priority Data:
62/443,75508.01.2017US
Title (EN) METHODS FOR DECREASING INJURIES ASSOCIATED WITH INTRAOPERATIVE HYPOTENSION
(FR) PROCÉDÉS DE RÉDUCTION DES LÉSIONS ASSOCIÉES À L’HYPOTENSION PEROPÉRATOIRE
Abstract:
(EN) The present disclosures provides methods for decreasing injuries associated with intraoperative hypotension by intravenously administering to a subject a therapeutically effective amount of a fat emulsion, following a period of intraoperative hypotension and after the subject's mean arterial blood pressure has recovered. The disclosure also provides methods for preventing injuries associated with intraoperative hypotension, particularly for surgical candidates that have an increased risk for intraoperative hypotension. Non-limiting examples of injuries contemplated herein include myocardial injury, myocardial infarction, and acute kidney injury.
(FR) La présente invention concerne des procédés pour diminuer les lésions associées à l’hypotension peropératoire par administration intraveineuse à un sujet d’une quantité thérapeutiquement efficace d’une émulsion de graisse, après une période d’hypotension peropératoire et après que la pression artérielle moyenne du sujet soit rétablie. L’invention concerne en outre des procédés pour prévenir les lésions associées à l’hypotension peropératoire, en particulier pour des candidats chirurgicaux qui présentent un risque accru d’hypotension peropératoire. Des exemples non limitatifs de lésions dans le contexte de l’invention comprennent une lésion myocardique, un infarctus du myocarde et une lésion rénale aiguë.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)