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1. (WO2018129304) TRANSDERMAL DRUG DELIVERY DEVICES AND METHODS

Pub. No.:    WO/2018/129304    International Application No.:    PCT/US2018/012568
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Sat Jan 06 00:59:59 CET 2018
IPC: A61M 5/00
A61M 5/14
A61M 5/142
A61M 5/145
Applicants: CHRONO THERAPEUTICS INC.
Inventors: JOHNSTON, Andrew, L.
SCHALLER, Michael, P.
PETERSON, Bryce
GELSTON, Kevin
Title: TRANSDERMAL DRUG DELIVERY DEVICES AND METHODS
Abstract:
A transdermal drug delivery device includes a reservoir, a transdermal membrane, a piston, a control rod, a spring, and a rotational cam. The reservoir is configured to hold a formulation. The transdermal membrane is configured to allow the formulation from the reservoir to pass therethrough. The piston is configured to move into the reservoir. The control rod is attached to the piston and includes a plurality of teeth thereon. The spring is configured to apply force to the control rod in the direction of the reservoir. The rotational cam has a first camming surface and a second camming surface that are configured to engage with the plurality of teeth. The rotational cam, when rotated, is configured to disengage the first camming surface from a first tooth of the plurality of teeth, thereby allowing the spring to advance the piston into the reservoir to expel the formulation onto the transdermal membrane.