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1. (WO2018129287) HETEROARYLDIAZEPINE DERIVATIVES AS RSV INHIBITORS
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Pub. No.: WO/2018/129287 International Application No.: PCT/US2018/012542
Publication Date: 12.07.2018 International Filing Date: 05.01.2018
IPC:
A61K 31/55 (2006.01) ,A61K 31/551 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
551
having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
Applicants: ENANTA PHARMACEUTICALS, INC.[US/US]; 500 Arsenal Street Watertown, MA 02472, US
Inventors: KIM, In, Jong; US
SHOOK, Brian, C.; US
BLAISDELL, Thomas, P.; US
YU, Jianming; US
PANARESE, Joseph; US
OR, Yat, Sun; US
Agent: HARLAN, Edgar, W.; US
ELMORE, Carolyn, S.; US
Priority Data:
62/443,16506.01.2017US
Title (EN) HETEROARYLDIAZEPINE DERIVATIVES AS RSV INHIBITORS
(FR) DÉRIVÉS D'HÉTÉROARYLDIAZÉPINE UTILISÉS COMME INHIBITEURS DU VRS
Abstract:
(EN) The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof. These compounds are useful for treating Respiratory Syncytial Virus (RSV) infection. The present invention further relates to pharmaceutical compositions comprising these compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering to the subject a pharmaceutical composition comprising a compound of the invention.
(FR) La présente invention concerne des composés de Formule (I), et des sels, esters, ou promédicaments pharmaceutiquement acceptables correspondants. Ces composés sont utiles pour traiter une infection par le Virus Rspiratoire Syncytial (VRS). La présente invention concerne également des compositions pharmaceutiques comportant lesdits composés, destinées à être administrées à un patient atteint d'une infection par le VRS. L'invention concerne également des méthodes de traitement d'une infection par le VRS chez un sujet en administrant au sujet une composition pharmaceutique comprenant un composé de la présente invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)