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1. (WO2018129268) PATTERNED DOSING OF IMMUNOSUPPRESSANTS COUPLED TO SYNTHETIC NANOCARRIERS

Pub. No.:    WO/2018/129268    International Application No.:    PCT/US2018/012503
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Sat Jan 06 00:59:59 CET 2018
IPC: A61K 38/00
A61K 39/00
A61K 45/00
A61K 47/32
A61K 9/51
A61K 31/436
A61K 31/444
A61K 47/50
A61P 37/06
Applicants: SELECTA BIOSCIENCES, INC.
Inventors: ILYINSKII, Petr
KISHIMOTO, Takashi, Kei
Title: PATTERNED DOSING OF IMMUNOSUPPRESSANTS COUPLED TO SYNTHETIC NANOCARRIERS
Abstract:
Provided herein are methods and related compositions for administering viral vectors and synthetic nanocarriers comprising an immunosuppressant. In some embodiments, the methods and compositions provided herein achieve improved transgene expression and/or immune response reduction, such as downregulated IgM and/or IgG immune responses.