WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Options
Query Language
Stem
Sort by:
List Length
1. (WO2018129206) DRUG REGIMEN FOR TREATMENT OF CEREBRAL ISCHEMIA
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/129206 International Application No.: PCT/US2018/012412
Publication Date: 12.07.2018 International Filing Date: 04.01.2018
IPC:
A61K 31/275 (2006.01) ,A61K 31/277 (2006.01) ,A61K 31/404 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
277
having a ring, e.g. verapamil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
Applicants: SHIMOJANI, LLC[US/US]; 409 Illinois Street San Francisco, CA 94158, US
Inventors: KAUVAR, Lawrence M.; US
JANIGRO, Damir; US
Agent: MURASHIGE, Kate H.; US
AHN, Sejin; US
AIKEN, Charity; US
BANKO, Max; US
BASOL, Erol, C.; US
Priority Data:
62/442,82605.01.2017US
62/470,08610.03.2017US
Title (EN) DRUG REGIMEN FOR TREATMENT OF CEREBRAL ISCHEMIA
(FR) RÉGIME DE MÉDICAMENT POUR LE TRAITEMENT DE L'ISCHÉMIE CÉRÉBRALE
Abstract:
(EN) Treatment of subjects experiencing cerebral ischemia is improved when the treatment employs a thrombolytic and an inhibitor against vascular endothelial growth factor receptor signal transduction (VEGF-RST) at a reduced, low dosage compared to that used to treat cancer patients. The treatment is also improved to permit point-of-care use by formulating protein drugs for long term stability at room temperature, providing doses appropriate for the method, and by combining the therapeutic agents with a point-of-care diagnostic for blood brain barrier integrity.
(FR) Le traitement de sujets subissant une ischémie cérébrale est amélioré lorsque le traitement utilise un agent thrombolytique et un inhibiteur contre la transduction de signal du récepteur du facteur de croissance de l'endothélium vasculaire (VEGF-RST) à une dose réduite et faible par rapport à celle utilisée pour traiter des patients atteints d'un cancer. Le traitement est également amélioré pour permettre une utilisation de point de soins par la formulation de médicaments protéiques pour une stabilité à long terme à température ambiante, à fournir des doses appropriées pour le procédé, et en combinant les agents thérapeutiques avec un diagnostic de point de soins pour l'intégrité de la barrière hémato-encéphalique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)