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1. (WO2018129202) COMPOSITIONS AND METHODS FOR THERAPY WITH DENGUE VIRUS

Pub. No.:    WO/2018/129202    International Application No.:    PCT/US2018/012408
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Fri Jan 05 00:59:59 CET 2018
IPC: A61K 35/76
A61K 47/42
A61K 9/00
A61K 9/08
A61K 9/19
A61P 35/00
Applicants: PRIMEVAX IMMUNO-ONCOLOGY, INC.
Inventors: LYDAY, Bruce W.
Title: COMPOSITIONS AND METHODS FOR THERAPY WITH DENGUE VIRUS
Abstract:
Described herein are compositions and methods for treating a disease, particularly a cancer, with a Dengue Virus and, optionally, primed dendritic cells recognizing a tumor antigen. Lysis protocols are described where the lysis does not result in complete or less than complete lysis of cells in order to provide cell surface molecules maintained in a cell surface-embedded state. Non-lethal Dengue virus strains are also provided for therapeutic purposes.