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1. (WO2018129199) NATURAL KILLER (NK) CELLS EXPRESSING AN ANTIGEN-SPECIFIC FUNCTIONAL T CELL RECEPTOR (TCR) COMPLEX, METHODS FOR PRODUCTION THEREOF, AND METHODS FOR THERAPEUTIC USE THEREOF

Pub. No.:    WO/2018/129199    International Application No.:    PCT/US2018/012403
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Fri Jan 05 00:59:59 CET 2018
IPC: A61K 35/17
C07K 14/705
C07K 14/725
C07K 16/28
C07K 16/30
C12N 5/0783
Applicants: NOVA SOUTHEASTERN UNIVERSITY
SABANCI UNIVERSITESI
Inventors: SUTLU, Tolga
DURU, Adil, Doganay
ERMAN, Batu
Title: NATURAL KILLER (NK) CELLS EXPRESSING AN ANTIGEN-SPECIFIC FUNCTIONAL T CELL RECEPTOR (TCR) COMPLEX, METHODS FOR PRODUCTION THEREOF, AND METHODS FOR THERAPEUTIC USE THEREOF
Abstract:
The invention provides modified Natural Killer (NK) cells expressing an antigen-specific functional T cell receptor (TCR) complex. These NK cells are used for T cell receptor (TCR) gene therapy in order to circumvent any risk of mispairing of the TCR a and β chains and to provide Major Histocompatibility Complex (MHC)-restricted antigen-specific cytotoxicity to the NK cells. The invention additionally provides methods for producing the modified NK cells, therapeutic compositions including the modified NK cells, and methods for using the modified NK cells in therapy of cancer, viral infections, autoimmunity, and graft versus host disease (GvHD).