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1. (WO2018129171) ENZYMATICALLY ACTIVATABLE PEPTIDE-REDOX MODULATOR CONJUGATES AND USE THEREOF
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Pub. No.: WO/2018/129171 International Application No.: PCT/US2018/012359
Publication Date: 12.07.2018 International Filing Date: 04.01.2018
IPC:
A61K 38/00 (2006.01) ,A61K 47/00 (2006.01) ,B82Y 5/00 (2011.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
5
Nano-biotechnology or nano-medicine, e.g. protein engineering or drug delivery
Applicants:
BRANDEIS UNIVERSITY [US/US]; 415 South Street Waltham, MA 02454, US
Inventors:
XU, Bing; US
Agent:
MERKEL, Edwin, V.; US
LEINBERG, Gunnar, G.; US
GOLDMAN, Michael, L.; US
TISCHNER, Tate, L.; US
O'GARA, Megan, T.; US
Priority Data:
62/443,38506.01.2017US
Title (EN) ENZYMATICALLY ACTIVATABLE PEPTIDE-REDOX MODULATOR CONJUGATES AND USE THEREOF
(FR) CONJUGUÉS PEPTIDE-MODULATEUR REDOX ACTIVABLES PAR VOIE ENZYMATIQUE ET LEUR UTILISATION
Abstract:
(EN) Disclosed are peptides capable of enzymatically-induced self-assembly to which is conjugated a redox modulator. These peptides are enzymatically responsive hydrogelators, and they can be used to form pericellular hydrogels/nanofibrils upon exposure to target cells that secrete or express a surface bound ectoenzyme having hydrolase activity suitable to induce peptide gelation. These materials, and compositions containing the same, can be used for inhibiting cancer cell migration, inhibiting cancer cell survival, and/or inhibiting cancer cell growth.
(FR) L'invention concerne des peptides capables d'auto-assemblage induit par voie enzymatique auquel est conjugué un modulateur redox. Ces peptides sont enzymatiquement sensible promoteurs d'hydrogel, et ils peuvent être utilisés pour former des hydrogels/nanofibriles péricellulaires lors d'une exposition à des cellules cibles qui sécrètent ou expriment une ectoenzyme liée à la surface ayant une activité hydrolase apte à induire la gélification peptidique. Ces matériaux, et les compositions les contenant, peuvent être utilisés pour inhiber la migration des cellules cancéreuses, inhiber la survie des cellules cancéreuses, et/ou inhiber la croissance des cellules cancéreuses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)