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1. (WO2018129155) SYSTEM AND METHOD FOR DETECTION OF CELLS
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Pub. No.: WO/2018/129155 International Application No.: PCT/US2018/012340
Publication Date: 12.07.2018 International Filing Date: 04.01.2018
IPC:
B01L 3/00 (2006.01) ,G01N 33/543 (2006.01) ,G01N 27/74 (2006.01) ,G01N 15/10 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27
Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
72
by investigating magnetic variables
74
of fluids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15
Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10
Investigating individual particles
Applicants:
MICROSENSOR LABS, LLC [US/US]; 1463 E. 53rd Street Chicago, IL 60615, US
Inventors:
LIU, Peng; US
Agent:
PENN, Amir, N.; US
Priority Data:
62/442,81805.01.2017US
Title (EN) SYSTEM AND METHOD FOR DETECTION OF CELLS
(FR) SYSTÈME ET PROCÉDÉ DE DÉTECTION DE CELLULES
Abstract:
(EN) A system and method for detection of cells is disclosed. Target cells, such as circulating tumor cells (CTCs), may be of interest. Magnetic beads may be bound to the target cells. After which, the target cells (with the magnetic beads attached thereto) may be identified using an applied magnetic field. In one example, magnetic sensors may be used to detect movement of the target cells responsive to an applied magnetic field. In another example, an optical sensor (such as a camera) may be used to detect movement of the target cells responsive to an applied magnetic field. Further, separate from identification of the target cells, the target cells may be sorted using an applied magnetic field. In this way, a magnetic field may be used in either or both of target cell identification or target cell sorting in order to detect target cells of interest.
(FR) La présente invention concerne un système et un procédé de détection de cellules. Des cellules cibles, telles que des cellules tumorales circulantes (CTC), peuvent présenter un intérêt. Des billes magnétiques peuvent être liées aux cellules cibles. Après quoi, les cellules cibles (avec les billes magnétiques fixées à celles-ci) peuvent être identifiées à l'aide d'un champ magnétique appliqué. Dans un exemple, des capteurs magnétiques peuvent être utilisés pour détecter un mouvement des cellules cibles en réponse à un champ magnétique appliqué. Dans un autre exemple, un capteur optique (tel qu'une caméra) peut être utilisé pour détecter un mouvement des cellules cibles en réponse à un champ magnétique appliqué. En outre, indépendamment de l'identification des cellules cibles, les cellules cibles peuvent être triées à l'aide d'un champ magnétique appliqué. De cette manière, un champ magnétique peut être utilisé dans l'identification de cellule cible ou le tri de cellule cible afin de détecter des cellules cibles d'intérêt.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)