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1. WO2018129122 - COST-EFFECTIVE RAMAN PROBE ASSEMBLY FOR SINGLE-USE BIOREACTOR VESSELS

Publication Number WO/2018/129122
Publication Date 12.07.2018
International Application No. PCT/US2018/012294
International Filing Date 04.01.2018
IPC
G01J 3/44 2006.01
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
28Investigating the spectrum
44Raman spectrometry; Scattering spectrometry
G01J 3/02 2006.01
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
02Details
C12M 1/34 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12M 1/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
G01N 21/85 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
84Systems specially adapted for particular applications
85Investigating moving fluids or granular solids
CPC
C12M 23/14
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
23Constructional details, e.g. recesses, hinges
02Form or structure of the vessel
14Bags
C12M 41/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
41Means for regulation, monitoring, measurement or control, e.g. flow regulation
G01J 3/0208
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
02Details
0205Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
0208using focussing or collimating elements, e.g. lenses or mirrors; performing aberration correction
G01J 3/0291
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
02Details
0291Housings; Spectrometer accessories; Spatial arrangement of elements, e.g. folded path arrangements
G01J 3/44
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
28Investigating the spectrum
44Raman spectrometry; Scattering spectrometry ; ; Fluorescence spectrometry
G01N 2021/0321
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
01Arrangements or apparatus for facilitating the optical investigation
03Cuvette constructions
0321One time use cells, e.g. integrally moulded
Applicants
  • KAISER OPTICAL SYSTEMS INC. [US]/[US]
Inventors
  • TEDESCO, James, M.
  • SLATER, Joseph, B.
Agents
  • POWERS, Christopher, R.
Priority Data
15/398,09604.01.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COST-EFFECTIVE RAMAN PROBE ASSEMBLY FOR SINGLE-USE BIOREACTOR VESSELS
(FR) ENSEMBLE DE SONDE RAMAN ÉCONOMIQUE POUR RÉCIPIENTS DE BIORÉACTEUR À USAGE UNIQUE
Abstract
(EN)
Systems and methods are used to couple an optical sampling probe to a port in a single-use bioreactor bag for in-process monitoring. A combination of re-useable and disposable components maintain precision while reducing costs. A disposable barb with an integral window, received by the port of the reaction vessel, is coupled to a re-useable optic component with a focusing lens. A separate focus alignment tool is used to set the lens position to a precise focal point before placement of the optic component into the barb. The fixture includes a window to simulate the window in a barb component, a target with a known spectral signature, and a probe head coupled to a spectral analyzer. The axial position of the lens is adjusted with respect to the spacer component to maximize the spectral signature from a sample target, whereupon the spacer component is bonded to the lens mount.
(FR)
L'invention concerne des systèmes et des procédés utilisés pour coupler une sonde d'échantillonnage optique à un orifice dans un sac de bioréacteur à usage unique pour une surveillance en cours de processus. Une combinaison de composants réutilisables et jetables garantit la précision tout en réduisant les coûts. Un ardillon jetable avec une fenêtre intégrée, accueilli par l'orifice du récipient de réaction, est couplé à un composant optique réutilisable doté d'une lentille de focalisation. Un outil d'alignement de foyer séparé est utilisé pour régler la position de la lentille à un point focal précis avant le placement du composant optique dans l'ardillon. L'appareil comprend une fenêtre permettant de simuler la fenêtre dans un composant d'ardillon, une cible dotée d'une signature spectrale connue, et une tête de sonde couplée à un analyseur spectral. La position axiale de la lentille est ajustée par rapport au composant d'espacement pour optimiser la signature spectrale à partir d'une cible d'échantillon, après quoi le composant d'espaceur est lié à la monture de lentille.
Also published as
Latest bibliographic data on file with the International Bureau