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1. (WO2018129122) COST-EFFECTIVE RAMAN PROBE ASSEMBLY FOR SINGLE-USE BIOREACTOR VESSELS
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Pub. No.: WO/2018/129122 International Application No.: PCT/US2018/012294
Publication Date: 12.07.2018 International Filing Date: 04.01.2018
IPC:
G01J 3/44 (2006.01) ,G01J 3/02 (2006.01) ,C12M 1/34 (2006.01) ,C12M 1/00 (2006.01) ,G01N 21/85 (2006.01)
G PHYSICS
01
MEASURING; TESTING
J
MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3
Spectrometry; Spectrophotometry; Monochromators; Measuring colours
28
Investigating the spectrum
44
Raman spectrometry; Scattering spectrometry
G PHYSICS
01
MEASURING; TESTING
J
MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3
Spectrometry; Spectrophotometry; Monochromators; Measuring colours
02
Details
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
34
Measuring or testing with condition measuring or sensing means, e.g. colony counters
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
84
Systems specially adapted for particular applications
85
Investigating moving fluids or granular solids
Applicants:
KAISER OPTICAL SYSTEMS INC. [US/US]; 371 Parkland Plaza Ann Arbor, MI 48103, US
Inventors:
TEDESCO, James, M.; US
SLATER, Joseph, B.; US
Agent:
POWERS, Christopher, R.; US
Priority Data:
15/398,09604.01.2017US
Title (EN) COST-EFFECTIVE RAMAN PROBE ASSEMBLY FOR SINGLE-USE BIOREACTOR VESSELS
(FR) ENSEMBLE DE SONDE RAMAN ÉCONOMIQUE POUR RÉCIPIENTS DE BIORÉACTEUR À USAGE UNIQUE
Abstract:
(EN) Systems and methods are used to couple an optical sampling probe to a port in a single-use bioreactor bag for in-process monitoring. A combination of re-useable and disposable components maintain precision while reducing costs. A disposable barb with an integral window, received by the port of the reaction vessel, is coupled to a re-useable optic component with a focusing lens. A separate focus alignment tool is used to set the lens position to a precise focal point before placement of the optic component into the barb. The fixture includes a window to simulate the window in a barb component, a target with a known spectral signature, and a probe head coupled to a spectral analyzer. The axial position of the lens is adjusted with respect to the spacer component to maximize the spectral signature from a sample target, whereupon the spacer component is bonded to the lens mount.
(FR) L'invention concerne des systèmes et des procédés utilisés pour coupler une sonde d'échantillonnage optique à un orifice dans un sac de bioréacteur à usage unique pour une surveillance en cours de processus. Une combinaison de composants réutilisables et jetables garantit la précision tout en réduisant les coûts. Un ardillon jetable avec une fenêtre intégrée, accueilli par l'orifice du récipient de réaction, est couplé à un composant optique réutilisable doté d'une lentille de focalisation. Un outil d'alignement de foyer séparé est utilisé pour régler la position de la lentille à un point focal précis avant le placement du composant optique dans l'ardillon. L'appareil comprend une fenêtre permettant de simuler la fenêtre dans un composant d'ardillon, une cible dotée d'une signature spectrale connue, et une tête de sonde couplée à un analyseur spectral. La position axiale de la lentille est ajustée par rapport au composant d'espacement pour optimiser la signature spectrale à partir d'une cible d'échantillon, après quoi le composant d'espaceur est lié à la monture de lentille.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)