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1. (WO2018129080) TARGET GENES IN MYC-DRIVEN NEOPLASIA

Pub. No.:    WO/2018/129080    International Application No.:    PCT/US2018/012238
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Thu Jan 04 00:59:59 CET 2018
IPC: A61K 31/337
A61K 31/395
A61K 31/513
A61K 31/519
A61K 45/06
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors: DEUTZMANN, Anja
FELSHER, Dean W.
LI, Yulin
Title: TARGET GENES IN MYC-DRIVEN NEOPLASIA
Abstract:
Methods are provided for treating a subject having a MYC-driven neoplasia. Aspects of the methods include administering to the subject an amount of an inhibitor of a target gene effective to treat the subject for the MYC-driven neoplasia. Methods are also provided for identifying a MYC-dependent target gene in a MYC-driven neoplasia. Aspects of the method include identifying the MYC-dependent target gene based on a phenotype detected in a first tumor cell line conditionally expressing MYC that is absent or quantitatively different in a second tumor cell line conditionally repressing MYC when the two cell lines are contacted with a CRISPR-based gene silencing agent. Kits and cell lines for practicing the methods of the disclosure are also provided.