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1. (WO2018129040) MODULATING NUDIX HOMOLOGY DOMAIN (NHD) WITH NICOTINAMIDE MONONUCLEOTIDE ANALOGS AND DERIVATIVES OF SAME

Pub. No.:    WO/2018/129040    International Application No.:    PCT/US2018/012182
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Thu Jan 04 00:59:59 CET 2018
IPC: A61K 31/706
A61P 35/00
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventors: SINCLAIR, David, A.
LI, Jun
NORMINGTON, Karl D.
Title: MODULATING NUDIX HOMOLOGY DOMAIN (NHD) WITH NICOTINAMIDE MONONUCLEOTIDE ANALOGS AND DERIVATIVES OF SAME
Abstract:
The invention provides methods of modulating and regulating NHD protein-protein interactions through nicotinamide mononucleotide, analogs and derivatives thereof, such as NAD+. Such modulation may be useful in methods of treating and preventing cancer, aging, cell death, radiation damage, radiation exposure, among others, may improve DNA repair, cell proliferation, cell survival, among others, and may increase the life span of a cell or protect it against certain stresses, among others.