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1. (WO2018129039) MODULATING NUDIX HOMOLOGY DOMAIN (NHD) WITH NICOTINAMIDE MONONUCLEOTIDE ANALOGS AND DERIVATIVES OF SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/129039 International Application No.: PCT/US2018/012181
Publication Date: 12.07.2018 International Filing Date: 03.01.2018
IPC:
A61K 31/706 (2006.01) ,A61P 35/00 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE[US/US]; 17 Quincy Street Cambridge, MA 02138, US
Inventors: SINCLAIR, David, A.; US
LI, Jun; US
Agent: SMITH, Deann, F.; US
BROW, William, E.; US
AKHIEZER, Alexander; US
BLOUNT, Jennifer, V.; US
ABELLEIRA, Susan, M.; US
Priority Data:
62/442,24704.01.2017US
Title (EN) MODULATING NUDIX HOMOLOGY DOMAIN (NHD) WITH NICOTINAMIDE MONONUCLEOTIDE ANALOGS AND DERIVATIVES OF SAME
(FR) MODULATION DU DOMAINE D'HOMOLOGIE NUDIX (NHD) AU MOYEN D'ANALOGUES DE MONONUCLÉOTIDE DE NICOTINAMIDE ET LEURS DÉRIVÉS
Abstract:
(EN) The invention provides methods of modulating and regulating NHD protein-protein interactions through nicotinamide mononucleotide, analogs and derivatives thereof, such as NAD+. Such modulation may be useful in methods of treating and preventing cancer, aging, cell death, radiation damage, radiation exposure, among others, may improve DNA repair, cell proliferation, cell survival, among others, and may increase the life span of a cell or protect it against certain stresses, among others.
(FR) L'invention concerne des procédés de modulation et de régulation d'interactions protéine-protéine NHD par l'intermédiaire de mononucléotide de nicotinamide, d'analogues et de dérivés associés, tels que le NAD+. Une telle modulation peut être utile dans des méthodes de traitement et de prévention du cancer, du vieillissement, de la mort cellulaire, de lésions par rayonnement, de l'exposition au rayonnement, entre autres, peut améliorer la réparation de l'ADN, la prolifération cellulaire, la survie cellulaire, entre autres, et peut augmenter la durée de vie d'une cellule ou la protéger contre certains stress, entre autres.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)