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1. (WO2018128828) NOVEL HEPCIDIN MIMETICS AND USES THEREOF

Pub. No.:    WO/2018/128828    International Application No.:    PCT/US2017/067764
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Fri Dec 22 00:59:59 CET 2017
IPC: C07K 7/06
C07K 14/575
C07K 7/08
Applicants: BAYER HEALTHCARE LLC
BAYER PHARMA AG
BAYER AG
Inventors: BIERER, Donald
POOK, Elisabeth
STAMPFUSS, Jan
FELDMAN, Richard I.
ALT, Carsten
Title: NOVEL HEPCIDIN MIMETICS AND USES THEREOF
Abstract:
The present invention relates to novel peptides acting as hepcidin mimetics, as well as analogues and derivatives thereof. The invention further relates to compositions comprising the peptides of the present invention, and to the use of the peptides in the prophylaxis and treatment of hepcidin-associated disorders, including prophylaxis and treatment of iron overload diseases such as hemochromatosis, iron-loading anemias such as thalassemia, and diseases being associated with ineffective or augmented erythropoiesis, as well as further related conditions and disorders described herein.