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1. (WO2018128691) NON-HUMAN ANIMALS HAVING AN ENGINEERED IMMUNOGLOBULIN LAMBDA LIGHT CHAIN LOCUS

Pub. No.:    WO/2018/128691    International Application No.:    PCT/US2017/060006
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Sat Nov 04 00:59:59 CET 2017
IPC: A01K 67/027
C12N 15/90
C12N 15/85
C07K 16/00
Applicants: REGENERON PHARMACEUTICALS, INC.
Inventors: GUO, Chunguang
HARRIS, Faith
VORONINA, Vera
MCWHIRTER, John
LEVENKONA, Natasha
MACDONALD, Lynn
TU, Naxin
MURPHY, Andrew, J.
Title: NON-HUMAN ANIMALS HAVING AN ENGINEERED IMMUNOGLOBULIN LAMBDA LIGHT CHAIN LOCUS
Abstract:
Non-human animals (and/or non-human cells) and methods of using and making the same are provided, which non-human animals (and/or non-human cells) have a genome comprising human antibody-encoding sequences (i.e., immunoglobulin genes). Non-human animals described herein express antibodies that contain human Igλ light chains, in whole or in part. In particular, non-human animals provided herein are, in some embodiments, characterized by expression of antibodies that contain human Igλ light chains, in whole or in part, that are encoded by human Igλ light chain-encoding sequences inserted into an endogenous Igλ light chain locus of said non-human animals. Methods for producing antibodies from non-human animals are also provided.