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1. WO2018128687 - COSMETIC APPEARANCE OF SKIN

Publication Number WO/2018/128687
Publication Date 12.07.2018
International Application No. PCT/US2017/059947
International Filing Date 03.11.2017
IPC
A61K 8/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
04Dispersions; Emulsions
A61K 8/19 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
19containing inorganic ingredients
A61K 8/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
34Alcohols
A61M 5/19 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
178Syringes
19having more than one chamber
A61M 5/315 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
178Syringes
31Details
315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod; Appliances on the rod for facilitating dosing
A61M 5/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
44having means for cooling or heating the devices or media
CPC
A61K 2800/81
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2800Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
81Preparation or application process involves irradiation
A61K 2800/91
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2800Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
91Injection
A61K 8/0204
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
0204Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
A61K 8/044
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
04Dispersions; Emulsions
044Suspensions
A61K 8/19
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
19containing inorganic ingredients
A61K 8/345
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
34Alcohols
345containing more than one hydroxy group
Applicants
  • VELIS, Christopher, J.P [US]/[US]
  • MILLER, Karen [US]/[US]
Inventors
  • VELIS, Christopher, J.P
  • MILLER, Karen
Agents
  • MEYERS, Thomas, C.
  • LEONARDO, Mark, S.
  • MELLINO, Marla, L.
  • MAGGIN, Benjamin, D.
  • MEYERS, Thomas, C.
Priority Data
62/424,14618.11.2016US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COSMETIC APPEARANCE OF SKIN
(FR) ASPECT COSMÉTIQUE DE LA PEAU
Abstract
(EN)
The present invention is directed to targeted delivery of a cold slurry underneath a patient's skin to improve the cosmetic appearance of the skin. The "target" tissue can be muscle tissue that when cooled cannot contract and cause wrinkles/lines in the skin to appear. The target tissue can also be adipose tissue that causes overlying tissue to sag and form wrinkles/lines. The cold slurry induces apoptosis, and reduces the size of the tissue, and causes the connective tissue supporting the skin to thicken and tighten, thereby reducing wrinkles/lines. Skin can also be tightened with cold slurry injected into the dermis layer of the skin or within the layers of the oral mucosa making a cold slurry treatment ideal for reducing the appearance of baggy skin after a patient loses weight and or for treating obstructive sleep apnea. Cold slurry can also be used to treat cellulite and acne.
(FR)
La présente invention concerne l’administration ciblée d’une suspension concentrée froide sous la peau d’un patient pour améliorer l’aspect cosmétique de la peau. Le tissu "cible" peut être un tissu musculaire qui, lorsqu’il est refroidi, ne peut pas se contracter et causer l’apparition de rides/lignes dans la peau. Le tissu cible peut également être un tissu adipeux qui amène le tissu sus-jacent à s’affaisser et former des rides/lignes. La suspension concentrée froide induit l’apoptose, et réduit la taille du tissu, et amène le tissu conjonctif soutenant la peau à s’épaissir et à se resserrer, de façon à réduire les rides/lignes. La peau peut également être resserrée avec une suspension concentrée froide injectée dans la couche de derme de la peau ou dans les couches de la muqueuse buccale, ce qui rend un traitement de suspension concentrée froide idéal pour réduire l’aspect de peau flasque après que le patient ait perdu du poids et ou pour traiter l’apnée obstructive du sommeil. La suspension concentrée froide peut également être utilisée pour traiter la cellulite et l’acné.
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