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1. (WO2018128664) 18F-LABELED COMPOUNDS FOR PET IMAGING AND USES THEREOF
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Pub. No.: WO/2018/128664 International Application No.: PCT/US2017/057595
Publication Date: 12.07.2018 International Filing Date: 20.10.2017
IPC:
A61K 49/06 (2006.01) ,A61K 51/00 (2006.01) ,A61K 31/404 (2006.01) ,A61P 35/00 (2006.01) ,A61K 101/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
101
Radioactive non-metals
02
Halogens
Applicants:
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; 109 Church St. Chapel Hill, North Carolina 27516, US
Inventors:
LI, Zibo; US
WU, Zhanhong; US
GIGLIO, Ben; US
MOSCHOS, Stergios; US
Agent:
SCHWARTZMAN, Robert A.; US
Priority Data:
62/410,68120.10.2016US
Title (EN) 18F-LABELED COMPOUNDS FOR PET IMAGING AND USES THEREOF
(FR) COMPOSÉS MARQUÉS AU 18F POUR L'IMAGERIE TEP, ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) The present invention relates to 18F-labeled compounds suitable for positron emission tomography (PET) imaging. The invention further relates to the use of these compounds for carrying out PET scans, imaging the indoleamine 2,3-dioxygenase, pathway, predicting the responsiveness of a subject with a solid tumor to therapies including immunotherapy such as PD-1/PD-L1 inhibition, and determining whether a solid tumor in a subject contains tumor-infiltrating immune cells.
(FR) La présente invention concerne des composés marqués au 18F adaptés à l'imagerie par tomographie par émission de positons (TEP). La présente invention se rapporte en outre à l'utilisation de ces composés pour réaliser des balayages TEP, pour imager la voie de l'indoléamine 2,3-dioxygénase, pour prédire la réponse d'un sujet avec une tumeur solide à des thérapies incluant une immunothérapie telle que l'inhibition de PD-1/PD-L1, et pour déterminer si une tumeur solide chez un sujet contient des cellules immunitaires infiltrant la tumeur.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)