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1. (WO2018128544) BIOMARKERS FOR SELECTING PATIENT GROUPS, AND USES THEREOF.

Pub. No.:    WO/2018/128544    International Application No.:    PCT/NL2018/050008
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Tue Jan 09 00:59:59 CET 2018
IPC: C12Q 1/6886
Applicants: AGENDIA N.V.
Inventors: TIAN, Sun
GLAS, Annuska Maria
BERNARDS, Rene
Title: BIOMARKERS FOR SELECTING PATIENT GROUPS, AND USES THEREOF.
Abstract:
The invention relates to a method for typing a sample of a cancer patient for an activated or non-activated TGF beta signaling pathway, comprising the steps of providing a sample from a cancer patient, whereby the sample comprises gene expression products from a cancer cell of said patient, determining a gene expression level for at least five genes listed in Table 4, comparing said determined gene expression level to a reference gene expression level of said genes in a reference sample of a cancer patient, said reference sample comprising cancer cells having an activated or non-activated TGF beta signaling pathway, and typing said sample on the basis of the comparison of the determined gene expression level and the reference gene expression level.