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1. (WO2018128517) PHARMACEUTICAL COMPOSITION CONTAINING NICLOSAMIDE FOR TREATING OR PREVENTING CANCER RELATING TO Ras CANCER GENE-TARGETED THERAPY
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Pub. No.: WO/2018/128517 International Application No.: PCT/KR2018/000396
Publication Date: 12.07.2018 International Filing Date: 09.01.2018
IPC:
A61K 31/167 (2006.01) ,A61K 45/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
167
having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants:
연세대학교 산학협력단 INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY [KR/KR]; 서울시 서대문구 연세로 50 50, Yonsei-ro Seodaemun-gu Seoul 03722, KR
Inventors:
육종인 YOOK, Jong In; KR
김현실 KIM, Hyun Sil; KR
김남희 KIM, Nam Hee; KR
노경태 NO, Kyoung Tai; KR
최지원 CHOI, Ji Won; KR
안성용 AHN, Sung Yong; KR
Agent:
이처영 LEE, Cheo Young; KR
장제환 CHANG, Je Hwan; KR
Priority Data:
10-2017-000287009.01.2017KR
Title (EN) PHARMACEUTICAL COMPOSITION CONTAINING NICLOSAMIDE FOR TREATING OR PREVENTING CANCER RELATING TO Ras CANCER GENE-TARGETED THERAPY
(FR) COMPOSITION PHARMACEUTIQUE CONTENANT DU NICLOSAMIDE POUR LE TRAITEMENT OU LA PRÉVENTION DU CANCER DANS LE CADRE D'UN TRAITEMENT CIBLANT L'ONCOGÈNE RAS
(KO) 니클로사미드를 함유하는 Ras 암유전자 표적치료 관련 암의 치료 또는 예방용 약학 조성물
Abstract:
(EN) The present invention relates to: a composition containing niclosamide or pharmaceutically acceptable salts thereof as an active ingredient, for inhibiting Ras; and a pharmaceutical composition containing niclosamide or pharmaceutically acceptable salts thereof as an active ingredient, for treating cancer recurring due to Ras activation. According to the present invention, cancer recurring due to Ras activation can be effectively prevented or treated using niclosamide, which is a safe drug approved by the FDA.
(FR) La présente invention concerne : une composition contenant comme principe actif du niclosamide ou des sels pharmaceutiquement acceptables de ce dernier, servant à inhiber Ras; et une composition pharmaceutique, contenant comme principe actif du niclosamide ou des sels pharmaceutiquement acceptables de ce dernier, utilisée pour traiter une récurrence du cancer liée à une activation de Ras. Selon la présente invention, une récurrence du cancer liée à une activation de Ras peut être efficacement empêchée ou traitée à l'aide du niclosamide, qui est un médicament sûr approuvé par la FDA.
(KO) 본 발명은 니클로사미드 또는 그의 약학적으로 허용가능한 염을 유효성분으로 함유하는 Ras 억제용 조성물 및 니클로사미드 또는 그의 약학적으로 허용가능한 염을 유효성분으로 함유하는 Ras 활성화에 의해 재발되는 암에 대한 치료용 약학 조성물에 관한 것으로, 본 발명에 따르면, FDA에서 승인받은 안전한 약물인 니클로사마이드를 이용하여, Ras에 의하여 재발되는 암을 효과적으로 예방 또는 치료할 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)