Search International and National Patent Collections

1. (WO2018128386) METHOD FOR SYNTHESIZING BETA-SUBSTITUTED GAMMA-NITRO DITHIOESTER COMPOUND, BETA-SUBSTITUTED GAMMA-NITRO DITHIOESTER COMPOUND PREPARED THEREBY, NOVEL GAMMA-AMINO ACID DERIVATIVE COMPOUND INDUCED THEREBY, AND METHOD FOR PREPARING BETA-SUBSTITUTED GAMMA-AMINOBUTYRIC ACID DERIVATIVE COMPOUND

Pub. No.:    WO/2018/128386    International Application No.:    PCT/KR2018/000120
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Thu Jan 04 00:59:59 CET 2018
IPC: C07C 327/22
B01J 31/02
Applicants: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
성균관대학교산학협력단
Inventors: SONG, Choong Eui
송충의
SIM, Jae Hun
심재훈
Title: METHOD FOR SYNTHESIZING BETA-SUBSTITUTED GAMMA-NITRO DITHIOESTER COMPOUND, BETA-SUBSTITUTED GAMMA-NITRO DITHIOESTER COMPOUND PREPARED THEREBY, NOVEL GAMMA-AMINO ACID DERIVATIVE COMPOUND INDUCED THEREBY, AND METHOD FOR PREPARING BETA-SUBSTITUTED GAMMA-AMINOBUTYRIC ACID DERIVATIVE COMPOUND
Abstract:
Disclosed is a method for synthesizing a gamma-nitro dithioester derivative compound (a γ-nitro dithioester compound). The gamma-nitro dithioester derivative compound may be synthesized by subjecting a nitroalkene compound having two carbon-containing substituents at the beta position (a β,β-disubstituted nitroalkene compound) and a dithiomalonate compound to the Michael reaction in water or an aqueous inorganic salt solution under the presence of a catalyst comprising a base, and the gamma-nitro dithioester derivative compound synthesized thereby has two carbon-containing substituents at the beta position.