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1. (WO2018127927) COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES

Pub. No.:    WO/2018/127927    International Application No.:    PCT/IL2018/050031
Publication Date: Fri Jul 13 01:59:59 CEST 2018 International Filing Date: Wed Jan 10 00:59:59 CET 2018
IPC: A61K 47/55
C07J 1/00
C12N 15/11
Applicants: APOSENSE LTD.
Inventors: ZIV, Ilan
DUBROVSKY, Joseph
GRIMBERG, Hagit
Title: COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
Abstract:
A system for delivery of drugs, and especially genetic drugs such as siRNA or antisense oligonucleotides (ASO) across biological membranes is provided. It comprises a trans- membrane delivery moiety, energized by the membrane internal electrical field, and a redox-sensitive disulfide moiety, designed to be reduced at the cytoplasm, thus releasing the cargo drug to exert its pharmaceutical effects at its target sites.